Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) through Inhibition of Mitochondrial Oxidative Stress in Rats

Figure 3

MB suppresses mRNA expression of hepatic cholesterol homeostasis-related genes. qRT-PCR analysis for ACC, FAS, SCD-1, and SREBP-1c was performed in HFD-fed rats after MB treatment for 10 weeks (n=10 per group). The qRT-PCR analysis was conducted in triplicate with five independent samples. Data are mean ± standard error of the mean (SEM). Significance was measured using one-way analysis of variance (ANOVA) followed by Bonferroni’s post hoc test. P < 0.01 and P < 0.005 vs. control group; P < 0.05, P < 0.01 and P < 0.001 vs. HFD-fed group. Con: control group; Veh: vehicle-treated group; MB 100 and 200, 100, and 200 mg/kg mulberry extracts-treated groups. HFD, high fat diet.