Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) through Inhibition of Mitochondrial Oxidative Stress in Rats

Figure 5

MB preserves activities of mitochondrial OXPHOS complexes and ATP contents in HFD-induced NAFLD. Activities of mitochondrial OXPHOS complexes, including (a) complex I and (b) complex II, were measured in HFD-fed rats after MB treatment for 10 weeks (n=10 per group). (c) ATP contents were luminometrically measured in HFD-fed rats after MB treatment for 10 weeks (n=10 per group). Data are mean ± standard error of the mean (SEM). Significance was measured using one-way analysis of variance (ANOVA) followed by Bonferroni’s post-hoc test. P < 0.05, P < 0.01, and P < 0.005 vs. control group; P < 0.01 and P < 0.001 vs. HFD-fed group were measured in HFD-fed rats after MB treatment for 10 weeks (n=10 per group). (c) ATP contents were luminometrically measured in HFD-fed rats after MB treatment for 10 weeks (n=10 per group). Data are mean ± standard error of the mean (SEM). Significance was measured using one-way analysis of variance (ANOVA) followed by Bonferroni’s post hoc test. P < 0.05, P < 0Con: control group; Veh: vehicle-treated group; MB 100 and 200, 100, and 200 mg/kg mulberry extracts-treated groups. HFD: high fat diet.

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