Small Peptides Compound Isolated from Agkistrodon with Antiarthritic Effect in Collagen-Induced Arthritis Rats

Figure 2

A schematic diagram of the effects and the principle molecular mechanisms of APE on Rheumatoid arthritis. APE reduces the recruitment of macrophages and thus downregulates the production of TNF-α, IL-6, and IL-1β, which are mainly released by macrophages.