Small Peptides Compound Isolated from Agkistrodon with Antiarthritic Effect in Collagen-Induced Arthritis Rats

Figure 9

Representative images of joint tissues stained with H&E, safranin O, and toluidine blue (original magnification, ×200). (a) Images stained with H&E revealed that synovial hyperplasia, inflammatory cell infiltration, the vascular pannus formation, and cartilage destruction were inhibited in the treated groups, especially the APE group when compared with the model group. The arrows indicated synovium. (b, c) Images stained with safranin O and toluidine blue showed that cartilage destruction and bone erosion were ameliorated in the treated groups, especially the APE group when compared with the model group. The triangles indicated articular cartilage.

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