Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay

Figure 2

H&E staining results after GP extracts treatment in NAFLD (original magnification 100x). (a) The normal group had a clear structure of the hepatic lobule, and there were no visible lesions. (b) In the model group, typical pathological characteristics such as inflammatory infiltration (black arrow) and macrovacuolar degeneration can be observed. ((c)–(e)) Treatment with GP (0.093, 0.28, and 0.84 g/kg) for six weeks significantly attenuated the inflammation and macrovacuolar degeneration in the liver. (f) Scoring of liver histology of NAFLD mice with GP treatment (mean ± SD). , compared with normal group, and , compared with model group.

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