Treatment of Urolithiasis with Medicinal Plant Salvia miltiorrhiza: A Nationwide Cohort Study

Table 3

Hazard ratios and 95% confidence intervals of calculus surgical treatment and any bleeding disorder associated with cumulative dose per year of Danshen among calculus patients using Danshen.

Used Danshen dose (g) per year		Number of events	Hazard ratio (95% CI)
			Crude	Adjusted^†
Event: calculus surgical treatment
Less than 417 g per year	2813	203	1 (reference)	1 (reference)
417–1096 g per year	3025	179	0.75 (0.62–0.92)	0.76 (0.62–0.93)
More than 1096 g per year	2698	192	0.92 (0.75–1.12)	0.94 (0.77–1.14)
Event: any bleeding disorders
Less than 417 g per year	2813	306	1 (reference)	1 (reference)
417–1096 g per year	3025	308	0.84 (0.71–0.98)	0.83 (0.71–0.97)
More than 1096 g per year	2698	303	0.94 (0.80–1.10)	0.95 (0.81–1.11)

Adjusted HR represented adjusted hazard ratio: mutually adjusted for sex, age, diabetes mellitus, urinary tract infection, hypertension, chronic kidney disease, and gout in Cox proportional hazard regression; < 0.05; < 0.01; tertiles are two cut points that will divide a dataset into three equal-sized groups. 417 g was 33rd percentage point and 1096 g was 66th percentage.