JYYS Granule Mitigates Renal Injury in Clinic and in Spontaneously Hypertensive Rats by Inhibiting NF-B Signaling-Mediated Microinflammation

Figure 3

JYYS granule decreases mRNA levels of profibrogenic genes and extracellular matrix decomposition in the kidneys of SHR. Real-time PCR was performed to determine the effects of JYYS granule on renal fibrotic genes and extracellular matrix genes (n=10). (a) Collagen-I; (b) fibronectin; (c) PAI-1; (d) TGF-β1; (e) TIMP-1; (f) collagen-IV; (g) MMP-9. The values were normalized to the GAPDH values and then expressed as relative quantification. Data are expressed as mean ± SD, n=10, #P <0.05 versus WKY group, Δ<0.05 versus SHR group.

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