Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Properties of Anthyllis henoniana (Coss.) Flowers Extracts in an Alloxan-Induced Rats Model of Diabetes
Table 8
Effect of the ethyl acetate flowers extract of Anthyllis henoniana on oxidative stress markers of different experimental groups of rats.
Groups
SOD (U/mg protein)
CAT (umole H2O2/min/mg protein)
GSH (ug/mg protein)
TBARS (nmol MDA/mg protein)
AOPP (nmol/mg protein)
Liver
Cont
70.12±1.30
1.70±1.32
40.12±1.25
11.00±0.25
0.16±1.25
Diab
60.01 ±1.20
0.80±0.02
12.3±0.02
28.50±1.21
0.67±1.05
Diab+ EAEx
64.55±7.39#
1.44±2.24###
27.07±1.9###@@@
16.38±9.36###@@
0.52±0.30###
Diab+ Acar
50.22± 1.39###
1.5±0.02##
30.00±0.4###
14.47±6.13###
0.32±0.02###
Rein
Cont
36.59±5.70
1.25±0.44
17.85±3.97
20.12±1.03
0.11±1.56
Diab
18.24±1.70
0.11±0.82
9.06±1.19
24.00±0.23
0.30±1.231
Diab+ EAEx
30.16±0.03###@@@
0.40±0.83##@
13.12 ±5.06###@
19.81±5.38###@
0.15±0.08###@@
Diab+ Acar
20.36±2.36###@@@
0.79±0.12###
19.00±0.17##
18.31±1.50###
0.17±0.25###
Pancreas
Cont
97.71±1.58
1.05±0.14
7.17±0.13
10.00±0.75
0.24±0.12
Diab
39.62±2.23
0.10±1.02
3.21±0.02
25.81±1.70
0.87±0.14
Diab+ EAEx
53.63±1.06###@@@
2.89±1.12###
8.50±6.10###
10.37±3.19###
0.33±0.13###
Diab+Acar
65.15±4.92###
0.81±1.12###
2.53±1.00###
12.71±1.73###
0.25±0.23###@@@
Values represent means ± SD (n = 8 for each group). Control groups (Cont) and diabetic control (Diab). Diab+ EAEx: diabetic rats treated with EAEx of Anthyllis henoniana at 400 mg/kg bw per day for 28 days; Diab+Acar: diabetic rats treated with acarbose at dose of 12 mg/kg bw per day for 28 days. Values differ significantly at<0.05 and < 0.001, as considered significant compared to control groups;#p<0.05## and p<0.01,###p < 0.001, as considered significant compared with diabetic rats; @p<0.05, @@p<0.01, and @@@p < 0.001, as considered significant compared with diabetic rats treated with acarbose.
