Sipjeondaebo-tang Alleviates Oxidative Stress-Mediated Liver Injury through Activation of the CaMKK2-AMPK Signaling Pathway

Figure 5

The effect of SDT on CCl₄-induced acute liver injury. (a) ALT and AST activities. Mice were orally administered SDT (300 or 500 mg/kg) for 4 days. One hour after last SDT administration, mice were intraperitoneally injected CCl₄ (0.5 mL/kg). Serum ALT (left) and AST (right) activities were detected 24 h after CCl₄ injection. (b) The representative histological profiles of the liver tissues. Scale bars indicate 120 μm (left). The numbers of degenerative hepatocytes (upper right) and infiltrated inflammatory cells (lower right) were quantified using an automated image analyzer. All values represent mean ± SD of four mice (for (a)) or eight historical fields from four mice (for (b)); significant versus vehicle-treated group, ^∗∗P < 0.01; significant versus CCl₄-treated group, ^##P < 0.01 and ^#P < 0.05; CV, central vein; PT, portal triad.

(a)

(b)