Research Article

Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of included studies.

First author, yearH. pylori diagnostic criteriaH. pylori eradicated criteriaAccompany diseaseSample size Mean age (years)TreatmentControlDuration of treatment (d)Adverse effects
(T/C)
TC

Ma 201113CUBT(+)
RUT (+)
13CUBT(-)
(4 wk later)
Peptic ulcer
or Chronic gastritis
96(54/42)40.94CBT
(4 tablets/time tid) +Control
C(500mg bid)
A(1000mg bid)
R(10mg bid)
7①②③④⑤⑦

Si
2013
13CUBT(+)
RUT (+)
13CUBT(-)
RUT(-)
(4 wk later)
Peptic ulcer90(45/45)43.5B
(0.4g tid)
+Control
CH(500mg bid)
A(100mg bid)
O(20mg bid)
7①②④⑤⑦

Hu 201513CUBT(+)13CUBT (-)
(4 wk later)
Peptic ulcer
or Chronic gastritis
106(53/53)49.45B
(0.5g tid)
+Control
CH(400mg bid)
A(1g bid) O(15mg bid)
14①②④⑤⑦

Qi
2013
14CUBT(+)14CUBT(-)
(2 wk later)
Not mentioned420(210/210)44.2B
(0.3mg tid)
+Control
C(0.25g bid)
A(1g bid)
R(20mg qd)
7①②③④⑤

Huang201614CUBT(+)14CUBT(-)
(2 wk later)
Peptic ulcer270(135/135)46.2B
(300mg tid)
+Control
C(500mg bid)
A(1000mg bid)
Or(20mg bid)
14Not mentioned

Chen
2013
14CUBT(+)14CUBT(-)
(4 wk later)
Not mentioned265(140/125)55B
(0.3g tid)
+Control
C(500mg bid)
A(1000mg bid)
O(20mg bid)
14①②⑤⑫⑭

Liu
2014
14CUBT(+)14CUBT(-)Chronic atrophic gastritis83(43/40)62.25BH
(60mg bid)
+Control
C(500mg bid)
A(1000mg bid)
O(20mg bid)
14①②⑩⑬

Huang2017RUT(+)RUT(-)
14 CUBT(-)
(4 wk later)
Peptic ulcer200(100/100)46.2B
(300mg tid)
+Control
C(0.5g bid)
A(1g bid)
O(20mg bid)
14①④⑤⑨⑭

Lu 2013Histology(+)
RUT(+)
Histology(-)
RUT(-)
13CUBT(-)
(4 wk later)
Peptic ulcer
or
chronic gastritis
162(84/78)40.87CBT
(4 tablets/time tid) +Control
C(500mg bid)
A(1000mg bid)
R(10mg bid)
7①②④⑤⑦

Dong 2013Histology(+)
RUT(+)
Histology(-)
RUT(-)
(4 wk later)
Not mentioned100(50/50)39.8BH
(120mg tid)
+Control
C(0.5g bid)
A(1g bid)
R(10mg bid)
7①②③④⑤⑥

Zhang
2014
Histology(+)
RUT(+)
Histology(-)
RUT(-)
Not mentioned200(100/100)43.3B
(120mg tid)
+Control
C(0.5g bid)
A(0.5g tid)
R(20mg bid)
7①④⑤⑧

Luo 2017RUT(+)RUT(-)
(4 wk later)
Peptic ulcer162(81/81)42.14CBT
(30mg tid)
+Control
C(0.5g bid)
A(0.5g bid)
O(20mg bid)
7①②⑤⑩⑮

Zou
2013
RUT(+)RUT(-)
(4 wk later)
Peptic ulcer100(50/50)47.75B
(0.3g tid)
+Control
C(500mg bid)
A(1000mg bid)
O(20mg bid)
14①⑪

①nausea, ②vomiting, ③abnormal taste, ④abdominal distension, ⑤diarrhea, ⑥anorexia, ⑦poor appetite, ⑧acid reflux, ⑨constipation, ⑩liver function injury, ⑪upper abdominal discomfort, ⑫rash, ⑬leukocyte reduction, ⑭dizzy, and ⑮abdominal pain.
UBT: urea breath test; RUT: rapid urease test; BH: berberine hydrochloride; B: berberine; CBT: compound berberine tablet; C: clarithromycin; A: amoxicillin; R: rabeprazole; O: omeprazole; CH: clarithromycin hydrochloride