Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes-Induced Murine Sinusitis Model

Figure 3

The colonies of S. pyogenes in nasal lavage collected from Shin’iseihaito extract- (SSHT-) treated mice). Mice were treated with SSHT according to the protocol shown in Figure 1. The nasal fluids were inoculated on TSAII sheep blood agar and incubated for 24 h. (a) Comparison of colony counts among phosphate-buffered saline (PBS) oral (p.o.), PBS intramuscular (i.m.), SSHT oral (p.o.), SSHT intramuscular (i.m.), or ampicillin sodium (100 mg/kg/day (i.m.), ABPC) treatment groups. (b) Dose-dependent effect of p.o. SSHT or (c) i.m. SSHT on nasal S. pyogenes infection. Data represent the mean ± SD (). N.S.: not significant. .

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(b)

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