Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes-Induced Murine Sinusitis Model

Figure 5

³H-thymidine-uptake assay of splenocytes collected from Shin’iseihaito extract- (SSHT-) treated Mice. Mice were treated with SSHT, phosphate-buffered saline (PBS) (p.o.), or ampicillin sodium (100 mg/kg/day, ABPC) (i.m.) according to the protocol shown in Figure 1, and then splenocytes were collected. (a) Comparison of splenocyte proliferation among PBS oral (p.o.), PBS intramuscular (i.m.), SSHT oral (p.o.), SSHT intramuscular (i.m.), or ampicillin sodium (100 mg/kg/day (i.m.), ABPC) treatment groups. (b) Dose-dependent effect of p.o. SSHT (c) and i.m. SSHT treatments on nasal S. pyogenes infection. Data represent the mean ± SD (). .

(a)

(b)

(c)