Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach

Figure 3

HB-cC-cT network of XFZYD. (a) and (b) The distribution of different candidate compounds and targets in the network (red: the Jun herbs-specific cC (a) and cT (b); aqua: the Chen herbs-specific cC (a) and cT (b); periwinkle: the Zuo-Shi herbs-specific cC (a) and cT (b); claybank: common cC (a) and cT (b) between the Jun and Chen herbs; blue: common cC (a) and cT (b) between the Jun and Zuo-Shi herbs; green: common cC (a) and cT (b) between the Chen and Zuo-Shi herbs; purple: common cC (a) and cT (b) among the 3 group of herbs. (c) The triangles with circle backgrounds represent the herbs (HB); the squares and circles represent the candidate compounds (cC) and candidate targets (cT). The red triangles, squares, and circles represent corresponding HB, cC, and cT in the Jun herbs; the same is to aqua representing the Chen herbs and periwinkle representing the Zuo-Shi herbs. The claybank squares and circles represent corresponding cC and cT overlap between the Jun and Chen herbs; the same is to blue representing the overlap between the Jun and Zuo-Shi herbs and the green representing the overlap between the Chen and Zuo-Shi herbs. The purple squares and circles represent the corresponding cC and cT shared by the 3 group of herbs. The size of the node is proportional to the value of degree.

(a)

(b)

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