TBI-related protein interaction network. (a) 21 hub proteins (red and green) were identified through the analysis of Therapeutic Target Database (TTD), as well as Online Mendelian Inheritance in Man (OMIM). 4 overlapped protein targets (green) were obtained between 21 hub proteins in TBI and candidate targets of XFZYD. Periwinkle: proteins from HPRD and STRING analyses were not targeted by XFZYD. (b) 47 candidate protein targets of XFZYD were screened for treating TBI. Yellow: candidate protein targets of XFZYD. The size of nodes is proportional to the value of degree.