Total Flavone of Rhododendron Improves Cerebral Ischemia Injury by Activating Vascular TRPV4 to Induce Endothelium-Derived Hyperpolarizing Factor-Mediated Responses

Figure 4

Effects of inhibitors of the SKca and IKca channels on TFR induced outward current (n=6 in each group).^∗∗P<0.01 versus TFR (2700 mg/L); ^##P<0.01 versus CIR+TFR+Apamin (0.05μmol/L)+TRAM-34 (1μmol/L). (a) TFR induced outward currents in the smooth muscle cell of CBA in CIR rats. (b) Effects of S channel blocker Apamin on outward currents induced by TFR. (c) Effects of I channel blockers TRAM-34 on outward currents induced by TFR. (d) Effects of Apamin plus TRAM-34 on outward currents induced by TFR. (e) Current-voltage curve.

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