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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 9185485, 8 pages
https://doi.org/10.1155/2018/9185485
Research Article

Buyang Huanwu Decoction Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats via Downregulation of Related Protein and Gene Expression

1Department of Traditional Chinese Medicine, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China
2Shanghai University of Traditional Chinese Medicine, Shanghai, China
3Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, China

Correspondence should be addressed to Xia Li; moc.361@ckjncc

Received 23 September 2017; Revised 14 January 2018; Accepted 28 January 2018; Published 28 February 2018

Academic Editor: Yoshiki Mukudai

Copyright © 2018 Xuan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. E. Fernandez and O. Eickelberg, “New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis,” The Lancet, vol. 380, no. 9842, pp. 680–688, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Mojiri-Forushani, A. A. Hemmati, M. A. Dehghani, A. R. Malayeri, and H. H. Pour, “Effects of herbal extracts and compounds and pharmacological agents on pulmonary fibrosis in animal models: a review,” Journal of Integrative Medicine, vol. 15, no. 6, pp. 433–441, 2017. View at Publisher · View at Google Scholar
  3. G. Raghu, H. R. Collard, J. J. Egan et al., “An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidencebased guidelines for diagnosis and management,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 6, pp. 788–824, 2011. View at Google Scholar
  4. B. Ley, H. R. Collard, and T. E. King Jr., “Clinical course and prediction of survival in idiopathic pulmonary fibrosis,” American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 4, pp. 431–440, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. X. Xu, H. Dai, J. Geng et al., “Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase,” Laboratory Investigation, vol. 95, no. 8, pp. 846–859, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. L.-H. Pan, K. Yamauchi, M. Uzuki et al., “Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF,” European Respiratory Journal, vol. 17, no. 6, pp. 1220–1227, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Tian, K. Lessan, J. Kahm, J. Kleidon, and C. Henke, “β1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway,” The Journal of Biological Chemistry, vol. 277, no. 27, pp. 24667–24675, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Jia, L. Q. He, and S. Xiao, “Interventional mechanisms of herbs or herbal extracts on renal interstitial fibrosis,” Journal of Integrative Medicine, vol. 14, no. 3, pp. 165–173, 2016. View at Google Scholar
  9. J.-N. Xu, H.-F. Que, and H.-J. Tang, “Effects and action mechanisms of Buyang Huanwu Decoction in wound healing of chronic skin ulcers of rats,” Journal of Chinese Integrative Medicine, vol. 7, no. 12, pp. 1145–1149, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S.-Z. Tan, C.-H. Liu, W. Zhang et al., “Feature changes of MMP-2/9 activities and TIMP-1/2 protein expressions during the progression of pulmonary fibrosis in rats,” Journal of Chinese Integrative Medicine, vol. 4, no. 4, pp. 402–407, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. T. E. King Jr., A. Pardo, and M. Selman, “Idiopathic pulmonary fibrosis,” The Lancet, vol. 378, no. 9807, pp. 1949–1961, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. E. B. Meltzer and P. W. Noble, “Idiopathic pulmonary fibrosis,” Orphanet Journal of Rare Diseases, vol. 3, no. 1, article 8, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. N. W. Todd, I. G. Luzina, and S. P. Atamas, “Molecular and cellular mechanisms of pulmonary fibrosis,” Fibrogenesis & Tissue Repair, vol. 5, no. 1, article 11, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. V. A. Polunovsky, B. Chen, C. Henke et al., “Role of mesenchymal cell death in lung remodeling after injury,” The Journal of Clinical Investigation, vol. 92, no. 1, pp. 388–397, 1993. View at Publisher · View at Google Scholar · View at Scopus
  15. A. A. Katzenstein and J. L. Myers, “Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 4, part 1, pp. 1301–1315, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. T. N. Wight and S. Potter-Perigo, “The extracellular matrix: an active or passive player in fibrosis?” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 301, no. 6, pp. G950–G955, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Igarashi, H. Okochi, D. M. Bradham, and G. R. Grotendorst, “Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair,” Molecular Biology of the Cell (MBoC), vol. 4, no. 6, pp. 637–645, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Frazier, S. Williams, D. Kothapalli, H. Klapper, and G. R. Grotendorst, “Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor,” Journal of Investigative Dermatology, vol. 107, no. 3, pp. 404–411, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. J. S. Hagood, J. A. Lasky, J. E. Nesbitt, and P. Segarini, “Differential expression, surface binding, and response to connective tissue growth factor in lung fibroblast subpopulations,” Chest, vol. 120, pp. 64S–66S, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. J. A. Lasky, L. A. Ortiz, B. Tonthat et al., “Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 275, no. 2, pp. L365–L371, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. C. L. Steffen, D. K. Ball-Mirth, P. A. Harding, N. Bhattacharyya, S. Pillai, and D. R. Brigstock, “Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblast cells in vitro,” Growth Factors, vol. 15, no. 3, pp. 199–213, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. H.-H. Hong, M. I. Uzel, C. Duan, M. C. Sheff, and P. C. Trackman, “Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-β1 and detection in human gingiva,” Laboratory Investigation, vol. 79, no. 12, pp. 1655–1667, 1999. View at Google Scholar · View at Scopus
  23. J. Lin, B. Liliensiek, M. Kanitz et al., “Molecular cloning of genes differentially regulated by TNF-α in bovine aortic endothelial cells, fibroblasts and smooth muscle cells,” Cardiovascular Research, vol. 38, no. 3, pp. 802–813, 1998. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Kikuchi, T. Kadono, H. Ihn et al., “Growth regulation in scleroderma fibroblasts: Increased response to transforming growth factor-β1,” Journal of Investigative Dermatology, vol. 105, no. 1, pp. 128–132, 1995. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Boes, B. L. Dake, B. A. Booth et al., “Connective tissue growth factor (IGFBP-rP2) expression and regulation in cultured bovine endothelial cells,” Endocrinology, vol. 140, no. 4, pp. 1575–1580, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Leask, “Scar wars: is TGF-β the phantom menace in scleroderma?” Arthritis Research & Therapy, vol. 8, no. 4, p. 213, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Xia, D. Diebold, R. Nho et al., “Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis,” The Journal of Experimental Medicine, vol. 205, no. 7, pp. 1659–1672, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. R. S. Nho, P. Hergert, J. Kahm, J. Jessurun, and C. Henke, “Pathological alteration of FoxO3a activity promotes idiopathic pulmonary fibrosis fibroblast proliferation on type I collagen matrix,” The American Journal of Pathology, vol. 179, no. 5, pp. 2420–2430, 2011. View at Publisher · View at Google Scholar · View at Scopus