Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug-Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica
Table 3
Half-maximal inhibitory concentrations of most effective extracts.
Species
IC50 (μg/mL) (mean ± SE)
CCRF-CEM
CEM/ADR5000
RF
K562
Lucena 1
RF
PBMC
Aldama tucumanensis
5.39 ± 0.2
17.56 ± 0.5
3.26
20.24 ± 1.2
29.44 ± 5.8
1.45
9.13 ± 1.84
Ambrosia elatior
5.84 ± 1.0
2.73 ± 0.6
0.47
19.16 ± 2.4
21.93 ± 2.9
1.14
4.01 ± 0.67
Baccharis artemisioides
1.15 ± 0.1
0.94 ± 0.2
0.82
1.90 ± 0.3
5.74 ± 0.1
3.02
0.95 ± 0.21
Baccharis coridifolia
0.37 ± 0.0
5.89 ± 0.8
15.92
0.51 ± 0.0
1.08 ± 0.1
2.12
0.08 ± 0.01
Dimerostemma aspilioides
1.60 ± 0.0
1.18 ± 0.3
0.74
6.89 ± 0.5
10.38 ± 1.1
1.51
2.69 ± 0.53
Gaillardia megapotamica
0.70 ± 0.0
1.21 ± 0.00
1.73
2.77 ± 0.0
5.95 ± 0.1
2.15
2.76 ± 0.52
Vernonanthura nudiflora
2.21 ± 0.0
6.38 ± 0.2
2.89
6.41 ± 0.9
10.76 ± 0.7
1.68
13.70 ± 1.06
doxorubicin
0.07 ± 0.000
>4
>571
0.78 ± 0.1
22.99 ± 1.1
29.47
0.39 ± 0.02
Results represent the mean ± SE. Means followed by the same letter in each row were not significantly different (Tukey, ). Statistical comparisons between extracts and doxorubicin were analyzed by one-tailed unpaired test. indicates , indicates , and indicates . Statistical comparisons between leukemia cells with respect to PBMC were analyzed by ANOVA-Tukey’s multiple comparison test. indicates , indicates , and indicates .
