In Vivo Antimalarial Activity of the 80 Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei

Table 1

Antimalarial activity of 80% methanol extract and solvent fractions of Gardenia ternifolia root barks against Plasmodium berghei in 4-day suppressive test.

Group	% Parasitemia	% Suppression	Survival Time
CON	53.95±0. 71	0.00	6.33±0.21
GT200	36.38±0.83	32.5	8.50±0.4
GT400	28.58±0.65	47.0	11.17±0.3
GT600	21.98±0.72	59.2	13.50±0.4
CQ25	0.00±0.00	100.0	28.00±0.0
CON	48.64±0.94	0.00	6.50±0.22
BF200	33.61±0.90	30.8	8.83±0.6
BF400	27.93±0.51	42.4	10.50±0.5
BF600	23.68±0.59	51.3	12.83±0.6
CQ25	0.00±0.00	100.0	28.00±0.0
CON	50.49±0.60	0.00	6.33±0.21
CF200	38.12±0.68	24.5	7.17±0.3
CF400	34.77±0.63	31.1	8.00±0.4
CF600	29.93±0.35	40.7	10.00±0.4
CQ25	0.00±0.00	100.0	28.00±0.0
CON	46.86±1.20	0.00	6.67±0.33
AF200	39.99±1.19	14.6	7.00±0.3
AF400	37.92±0.57	19.0	7.50±0.2
AF600	34.80±0.68	25.7	7.83±0.4
CQ25	0.00±0.00	100.0	28.00±0.0

Data are expressed as mean ± SEM (n=6); a, compared to CON; b, to CQ 25; c, to 200 mg/kg; d, to 400 mg/kg; e, 600 mg/kg: ¹p<0.05, ²p<0.01, ³p<0.001; CON, negative control, received distilled water 10 ml/kg; GT = crude extract of Gardenia ternifolia, BF = n-butanol fraction, CF = chloroform fraction, AF = aqueous fraction, and CQ = chloroquine; numbers (25,200,400,600) refer to dose in mg/kg.