In Vivo Antimalarial Activity of the 80 Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei

Table 2

Body weight and rectal temperature change of infected mice treated with crude extract and solvent fractions of Gardenia ternifolia root barks in 4-day suppressive test.

Group	Weight (gram)			Temperature (^0c)
	D0	D4	% Change	D0	D4	% Change
CON	25.76±1.17	21.65±0.94	-13.55	35.85±0.38	33.15±0.33	-7.51
GT200	26.78±1.34	24.73±1.41	-7.8	36.65±0.28	35.10±0.15	-4.2
GT400	27.37±1.01	26.37±1.16	-3.6	36.50±0.25	35.58±0.17	-2.5
GT600	28.51±0.56	28.46±0.81	-0.2	36.60±0.23	36.30±0.48	-0.8
CQ25	28.02±1.11	30.95±1.10	10.5	36.32±0.34	36.82±0.25	1.4
CON	27.78±0.49	24.04±0.53	-11.14	36.75±0.31	34.25±0.26	-6.80
BF200	28.91±0.48	26.81±0.42	-7.2	37.35±0.21	35.53±0.16	-4.8
BF400	29.24±0.31	28.09±0.24	-3.9	37.45±0.21	36.02±0.30	-3.8
BF600	27.93±0.48	27.77±0.60	-0.6	36.90±0.24	36.00±0.33	-2.4
CQ25	27.07±0.70	30.23±0.99	11.6	36.80±0.43	37.45±0.21	1.8
CON	26.33±1.15	22.44±0.97	-12.20	36.30±0.53	33.55±0.33	-7.54
CF200	26.85±0.98	24.15±1.24	-10.2	36.53±0.40	34.30±0.48	-6.1
CF400	27.60±0.62	25.43±0.67	-7.9	36.70±0.33	35.05±0.43	-4.5
CF600	28.41±0.63	27.20±0.60	-4.2	36.80±0.41	35.55±0.40	-3.3
CQ25	28.10±0.82	31.39±0.76	11.8	36.70±0.40	37.28±0.26	1.6
CON	26.93±0.73	23.65±0.90	-10.72	36.45±0.25	33.10±0.50	-9.21
AF200	27.74±0.85	25.04±0.91	-9.8	36.90±0.31	33.80±0.34	-8.4
AF400	26.92±0.79	24.60±0.76	-8.6	36.35±0.36	33.70±0.34	-7.2
AF600	28.61±0.61	26.34±0.65	-7.9	37.08±0.40	34.52±0.43	-6.9
CQ25	28.32±0.63	31.21±0.68	10.2	37.00±0.35	37.90±0.23	2.4

Data are expressed as mean ± SEM (n=6); a, compared to CON; b, compared to CQ 25 mg/kg; c, compared to 200 mg/kg; d, compared to 400 mg/kg; e, compared to 600 mg/kg; ¹p< 0.05; ²p<0.01, ³p<0.001; CON, negative control; GT = crude extract, BF = n-butanol fraction, CF = chloroform fraction, AF = aqueous fraction, and CQ = chloroquine; D₀ = pretreatment value on day zero, D₄ = posttreatment value on day four; numbers (25,200,400,600) refer to dose in mg/kg.