In Vivo Antimalarial Activity of the 80 Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei

Table 3

Effects of crude extract and fractions of Gardenia ternifolia root barks on packed cell volume of infected mice in 4-day suppressive test.

Group	Packed Cell Volume
	D0	D4	% change
CON	59.91±2.51	55.11±2.48	-7.99
GT200	64.86±1.79	62.57±1.90	-3.5
GT400	61.98±2.40	61.22±2.63	-1.2
GT600	56.96±1.43	57.00±1.40	0.0
CQ25	59.77±1.75	62.19±1.89	4.0
CON	63.68±2.72	59.11±2.73	-7.23
BF200	63.10±1.16	60.58±1.07	-3.9
BF400	61.09±1.95	60.11±1.99	-1.5
BF600	64.02±2.96	63.91±2.94	-0.1
CQ25	65.21±1.68	68.23±1.72	4.6
CON	65.15±1.91	60.26±1.81	-7.51
CF200	62.11±1.44	58.05±1.02	-6.4
CF400	58.97±1.52	56.62±1.47	-3.9
CF600	62.13±1.67	60.95±1.77	-1.9
CQ25	59.82±1.74	62.57±2.15	4.5
CON	64.14±3.90	59.55±3.78	-7.22
AF200	62.66±2.50	58.41±2.29	-6.7
AF400	64.71±2.30	60.86±2.07	-5.9
AF600	58.71±1.29	55.50±1.25	-5.4
CQ25	60.48±2.60	63.24±2.44	4.6

Data are expressed as mean ± SEM (n=6); a, compared to negative control; b, compared to CQ 25 mg/kg; c, compared to 200 mg/kg; d, compared to 400 mg/kg; e, compared to 600 mg/kg; ¹p< 0.05; ²p<0.01, ³p<0.001; CON, negative control (received 10 ml/kg distilled water); CQ, chloroquine; GT, G. ternifolia; D₀ = pretreatment value on day zero, D₄ = posttreatment value on day four; numbers (25,200,400,600) refer to dose in mg/kg.