In Vivo Antimalarial Activity of the 80 Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei

Table 4

Antimalarial activity of the hydroalcoholic extract of Gardenia ternifolia root barks against Plasmodium berghei in Rane’s test.

Group	% Parasitemia (D7)	% Inhibition	Survival Time
CON	38.12±0.75	0.00	7.17±0.17
GT200	24.29±0.39	36.2	9.00±0.2
GT400	18.26±0.61	52.1	11.50±0.4
GT600	14.02±0.81	63.2	14.00±0.5
CQ25	0.00±0.00	100.0	28.00±0.0

Data are expressed as mean ± SEM (n=6); a, compared to CON; b, compared to CQ 25 mg/kg; c, compared to 200 mg/kg; d, compared to 400 mg/kg; e, compared to 600 mg/kg; ¹p< 0.05; ²p<0.01, ³p<0.001; CON, negative control (received 10 ml/kg distilled water); CQ, chloroquine; GT = crude extract of G. ternifolia. Numbers (25,200,400,600) refer to dose in mg/kg.