In Vivo Antimalarial Activity of the 80 Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei

Table 7

Body weight and rectal temperature of Plasmodium berghei infected mice treated with crude extract of Gardenia ternifolia root barks in repository test.

Group	Weight (gram)			Temperature (^0c)
	D0	D7	% Change	D0	D7	% Change
CON	27.82±0.86	26.13±1.02	-6.19	36.90±0.36	34.98±0.45	-5.20
GT200	27.68±0.93	26.28±0.86	-5.0	36.75±0.29	35.25±0.29	-4.0
GT400	28.58±0.49	27.42±0.40	-4.0	37.20±0.22	35.98±0.27	-3.2
GT600	28.55±0.76	27.88±0.80	-2.3	36.80±0.24	36.17±0.38	-1.7
CQ25	28.54±0.64	28.63±0.76	0.2	37.00±0.31	36.85±0.36	-0.4

Data are expressed as mean ± SEM (n=6); a, compared to CON; b, compared to CQ 25 mg/kg; c, compared to 200 mg/kg; d, compared to 400 mg/kg; e, compared to 600 mg/kg; ¹p< 0.05; ²p<0.01, ³p<0.001; CON, negative control; CQ, chloroquine (positive control); GT, crude extract of G. ternifolia; D₀ = preinoculated value on day three, D₇ = postinoculated value on day seven; numbers (25,200,400,600) refer to dose in mg/kg.