Research Article

Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans 9-Tetrahydrocannabinol/Sesame Oil on Adjuvant-Induced Arthritis in Rats

Figure 1

Effect of treatments on left hind paw, body weight, and spleen index. (a) Macroscopic image of left hind paw at day 16 in following groups: (A) normal [N], (B) untreated AIA [A], (C) AIA treated with MTX [AM], (D) AIA treated with sesame oil [AS], and (E) AIA treated with Δ9-THC/sesame oil [AT]. (b) Mean macroscopic scores change, (c) body weight difference, and (d) spleen index among groups. All values are presented as mean ± SD of 8 rats per group. ∞∞∞∞p<0.0001 for A compared with N. p<0.05, p<0.01, p<0.001, p<0.0001 compared with A. ##p<0.01 and ####p<0.0001 compared with the positive control group AM.