Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza)

Figure 4

Docked poses of rosmarinic acid and daucosterol with ERp57. The left diagram represents the three-dimensional (3D) model of ERp57. The space-filling model in domains (a) and () indicates the catalytic residues CGHC on the left. The enlarged figures of the right side show the interaction between ERp57 and rosmarinic acid (top right) or daucosterol (bottom right). The green mode of ball and stick represents rosmarinic acid or daucosterol and the crystal structure of ERp57 domain with each monomer presented in ribbon diagram. Hydrogen bonding is shown as light blue dashed line.