Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus

Figure 8

Expression of SIRT1, PGC-1α, and NRF1. Representative cropped blots are exhibited, and the full-length blots are presented in Supplementary Figure (available here). All data are represented as the mean ± standard error (n = 7 per group). P < 0.05, P < 0.01, and P = 0.001 vs. the CF group. #P < 0.05 and ###P = 0.001 vs. the MDM group. △P < 0.05 and △△△P < 0.001 vs. the LDM group. $P < 0.05 vs. the HDM group. Abbreviations: CON: negative control; CQ: coenzyme Q10; HDM: high-dose modified Si-Ni-San; LDM: low-dose modified Si-Ni-San; MDM: medium-dose modified Si-Ni-San; NRF1: nuclear respiratory factor 1; PGC-1α: peroxisome proliferator-activated receptor gamma coactivator-1α; SIRT1: sirtuin 1; CF: untreated central fatigue.