Understanding the Role of Gui-Zhi-Fu-Ling-Capsules (Chinese Medicine) for Treatment of Endometriosis in the Rat Model: Using NMR Based Metabolomics

Table 2

Pathways and functional analysis of metabolites.

	Pathway	Total	Hits	Raw p	-ln(p)	Holm adjust	FDR	Impact
A	Glyoxylate and dicarboxylate metabolism	16	2	0.003287	5.7179	0.26623	0.23354	0.40741
B	Pyruvate metabolism	22	2	0.006219	5.0801	0.49752	0.23354	0.05583
C	Glycolysis or Gluconeogenesis	26	2	0.00865	4.7502	0.68333	0.23354	0.02862
D	Taurine and hypotaurine metabolism	8	1	0.044858	3.1043	1	0.81549	0.42857
E	Methane metabolism	9	1	0.050339	2.989	1	0.81549	0
F	Citrate cycle (TCA cycle)	20	1	0.10884	2.2178	1	1	0.05356
G	Primary bile acid biosynthesis	46	1	0.23476	1.4492	1	1	0.02976

The predicative pathways are (A) Glyoxylate and dicarboxylate metabolism; (B) Pyruvate metabolism; (C) Glycolysis or Gluconeogenesis; (D) Taurine and hypotaurine metabolism; (E) Methane metabolism; (F) Citrate cycle (TCA cycle); and (G) Primary bile acid biosynthesis. Based on the pathways and functional analysis of metabolites, Glycolysis or Gluconeogenesis has the most total number of compounds in the pathway based on the KEGG databases.
The total number of compounds in the pathway based on the KEGG databases.
The actual matched names and numbers of the predicted metabolites.
The P value calculated from the analysis.
The pathway impact value calculated.