Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 1

Review Article

The Method of Activating Blood and Dredging Collaterals for Reducing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies of the systematic review.

First authorYearSample size
(drop-out)
Mean age (year)
(median/range)
Cancer
Types
Common treatment
(regimen)
Interventions
(regimen, participants)
Comparators
(regimen, participants)
Main Outcomes

Herbal medicine for hand and foot baths or fumigation or compress or gel
Chen, Mou
[18]
201579 (0)50.12±10.21Gastric and colorectal
cancer
FOLFOX 4Hand and foot bath of Huoxue Tongluo decoction(30 min, tid for 2wks, n=42)No additional Tx. (n=37)(1)  Incidence rate
(NCI-CTC; sensory neuropathy)
(2)QoL (KPS)
(3)Adverse events
Li, Cai
[19]
201765 (0)I:53
C:56
colorectal
cancer
XELOX (d1-14, 3wks/cycle for 2 cycles)Hand and foot bath, fumigation of Wenjing Huoxue formula(15 min, qd for 6 wk, n=34)No additional Tx. (n=31)(1)Incidence rate
(Levi‘s grade)
(2)QoL (KPS)
(3)Adverse events
Lou
[20]
2014102(1)I:59.84±9.30 C:57.94±10.55Various types of cancerOxaliplatin based CTx.Hand and foot bath of Wenjing Tongluo formula(20 min, bid for 7 days, n=67)placbo(20 min, bid for 7 days, n=34)(1)Clinical improvement (NCI-CTC; sensory neuropathy,)
(2)NRS (pain)
(3)NCCN (pain)
(4) Adverse events
Qin
[21]
201268 (0)I:57.2±8.6 C:59.5±7.9Various types of cancer(1)Oxaliplatin/paclitaxel based CTx.
(2)AD pro injection (80ml qd)
(3) Thymopentin(1 mg qd)
(for 14 days)
Hand and foot bath of Network Vessel-freeing Formula(30 min, qd for 14 days, n=34)Cobamamide for intramuscular injection(1mg qd for 14 days, n=34)(1)Clinical effectiveness (Nimodipine trichotomy)
(2)Incidence rate (researcher’s own criteria)
(3)Adverse events
Shen
[22]
201560 (0)I:59.67±12.72 C:56.57±11.32Various types of cancer(1)Oxaliplatin based CTx.
(2)Mecobalamin for intramuscular injection (0.5 mg tiw)
(3)AD pro injection (50ml qd)
(4)Thymopentin for subcutaneous injection(1.6 mg biw)
(for 14 days)
Hand and foot bath of modified Huangqi-Guizhi Wuwu decoction(30 min, qd for 14 days, n=30)No additional Tx. (n=30)(1)Clinical improvement (NCI-CTC; sensory neuropathy,)
(2)Clinical symptom (GPCR-NCM)
(3)Adverse events
Tang
[23]
2014128(23)I:59.46±11.51 C:61.16±9.47Gastric and colorectal
cancer
Oxaliplatin based CTx (for 6-8 cycles)Hand and foot bath of Yangxue Wenjing Tongluo decoction (
during CTx, 20 min, bid, n=54)
No additional Tx. (n=51)(1)Incidence rate
(WHO grade)
(2)Clinical symptom (TCSS)
(3) Adverse events
Yi, Li
[24]
2017100 (0)Not mentionedcolorectal
cancer
Oxaliplatin based CTx.(21 d/cycle for 6 cycles)Hand and foot bath of Tongluo Zhibi decoction (during CTx, 30 min, qd for 6 cycles, n=50)Warm water for Hand and foot bath (during CTx, 30 min, qd for 6 cycles, n=50)(1)Incidence rate
(Levi‘s grade)
(2)QoL (KPS)
(3) Adverse events
Zhang
[25]
201564 (0)Not mentionedGastric and colorectal
cancer
FOLFOX 4Hand and foot bath of Tongjing, Huoxue formula (during CTx, 1000ml, 30 min, qd for 7 d, n=32)Warm water for Hand and foot bath (during CTx, 1000ml, 30 min, qd for 7 d, n=32)(1)Clinical improvement (Levi‘s grade, NCI-CTC)
(2)QoL (KPS)
Feng
[26]
2014120 (0)I:53.18±13.61 C:51.95±11.37Various types of cancer(1)Cisplatin based CTx.
(2)Glutathione (1500mg/m2,d1-7)
Herbal Compress (for 7 d, n=60)No additional Tx. (n=60)(1)Incidence rate
(WHO grade)
(2)Duration time
(3)Herbal related adverse events
Xu, Zhang
[27]
201867 (0)I:57.89±11.54 C:54.71±12.24Various types of cancerNot mentioned.(1)Xiaotan Tongluo Gel for external use(1 mL/cm2,14 d/cycle for 2 cycles, n=36)
(2)Mecobalamin tablets (0.5 mg tid)
(1)Placebo Gel for external use(1 mL/cm2,
14 d/cycle for 2 cycles, n=31)
(2)Mecobalamin tablets (0.5 mg tid)
(1)Clinical improvement (NCI-CTC; sensory neuropathy,)
(2)Clinical symptom (GPCR-NCM)
(3) NCV
(1)SNCV: median nerve/fibular nerve
(2)MNCV: median nerve/
fibular nerve

Herbal medicine for intravenous infusion
Chen, Huang
[28]
201858 (0)I:42-78
C:43-78
Gastric and colorectal
cancer
(1)FOLFOX4(2wks/cycle for 4 cycles)
(2)Methycobal Injection for Intramuscular injection (0.5 mg qd during CTx)
Astragalus injection for intravenous infusion(30ml qd during CTx, n=29)
No additional Tx. (n=29)(1)  Incidence rate
(WHO grade)
(2) QoL (KPS)
(3) NCV
(1)SNCV: median nerve/peroneus communis nerve
(2)MNCV: median nerve/ Peroneus communis nerve
Cheng
[29]
201436 (0)I:46
C:49
Various types of cancerOxaliplatin based CTx. (130mg/m2,d1,21d/cycle for 4 cycles)
Tanshinone IIA Sodium Sulfonate Injection for intravenous infusion (80mg qd for d1-3,n=18)(1)Tropisetron (5mg/d)
(2)dxm (5mg/d)
During CTx
(n=18)
(1)Incidence rate
(Levi‘s grade)
(2)SNCV/MNCV
(3)SOD/MDA
Cui
[30]
200940 (0)I:60
C:63
Gastric and colorectal
cancer
Oxaliplatin based CTx.(130mg/m2,d1, for 1 cycle)Astragalus injection for intravenous infusion(30ml qd for d1-7, n=20)No additional Tx. (n=20)(1)Incidence rate
(Levi‘s grade)
(2)NGF

Herbal medicine for oral dosage form
Li, Sun
[31]
201756 (0)I: 58.89±8.75C: 57.71±9.31Various types of cancern.c.Granulas of Chinese Medicine of modified Huangqi-Guizhi Wuwu and Shentong Zhuyu(10g, bid for 1month, n=28)Placebo(10g, bid for 1 month, n=28)(1)Clinical improvement (NCI-CTC, sensory neuropathy,)
(2)NRS (numbness)
(3)ECOG PS (EORTC QLQ-C30)
(4) Adverse events
Liu,
Zhou
[32]
201190 (5)I:61.47±9.05 C:60.43±9.48Various types of cancerOxaliplatin based CTx.(130mg/m2,d1, every 21 days/cycle, for 2 cycles)Wangqi Guizhi Wuwu decoction(100ml, bid for 42 days, during CTx, n=28)Mecobalamin (0.5 mg tid for 42 days, n=29)(1) Clinical improvement (Levi‘s grade)
(2)NCV
(1)SNCV: median nerve/fibular nerve
(2)MNCV: median nerve/
fibular nerve
(3)Effective rate
Peng
[33]
201596 (0)I:57.2
C:55.7
Gastric and colorectal
cancer
(1)mFOLFOX6(2 wks/cycle for 4 cycles)
(2)Calcium gluconate, magnesium sulfate for injection (before CTx, for 2 days)
Danggui Sini Decoction combined with Yanghe Decoction(150ml, ( bid for 8 wks, during CTx, n=48)No additional Tx. (n=48)(1)Incidence rate
(Levi‘s grade)
(2) NCV
(1)SNCV: median nerve/fibular nerve
(2)MNCV: median nerve/
fibular nerve
(3)Hemodynamic parameters
Chen, Yi [34]201670 (0)I:63.9±7.9 C:64.0±8.1colorectal
cancer
Oxaliplatin based CTx.(21 d/cycle for 4 cycles)Tongluo Zhibi decoction(1wk before CTx- the end, n=35)No additional Tx. (n=35)(1)Incidence rate (researcher’s own criteria)
(2)NGF
(3)SNCV/SNAPA
Shi
[35]
201056 (0)I:62.8
C:62.1
Gastric and colorectal
cancer
FOLFOX 4 (for 4 cycles)Wenjing Decoction
(bid for 2 months, during CTx, n=30)
No additional Tx. (n=26)Incidence rate
(Levi‘s grade)
Xu
[36]
201676 (0)I:45.3±5.8 C:44.9±5.5Ovarian cancerTP(21 d/cycle for 6 cycles)Modified Wangqi Guizhi Wuwu decoction(150ml, qd for 2 wks, during CTx, n=38)Mecobalamin tablets (0.5 mg tid for 2 wks, n=38)(1)Incidence rate (NCI-CTC; sensory neuropathy,)
(2) NCV
(1)SNCV: median nerve/fibular nerve
(2)MNCV: median nerve/
fibular nerve
Yu, Su
[37]
201450(1)I:58.4±5.3 C:57.6±4.7Various types of cancer(1)TP(21 d/cycle for 6 cycles)
(2)5-HT3 inhibitor
Jiawei Wangqi Guizhi Wuwu decoction (qd for 14 d/cycle, during CTx, for 6 cycles n=25)Mecobalamin tablets (0.5 mg, tid for 14 d/cycle during CTx, for 6 cycles, n=24)(1)Incidence rate
(WHO grade)
(2) NCV
(1)SNCV: median nerve/fibular nerve
(2)MNCV: median nerve/
fibular nerve

FOLFOX: folinic acid, fluorouracil, and oxaliplatin, XELOX: capecitabine and oxaliplatin, TP: paclitaxel and cisplatin, n.c.: no common treatment, Tx.: treatment, CTx.: chemotherapy, d:day, min:minute, qd: once daily, bid: twice a day, tid: three times a day, biw: twice a week; tiw: three times a week,
GPCR-NCM: Guiding Principles for Clinical Research of New Chinese Medicines, TCSS:Toronto Clinical Scoring System, NCI-CTC: National Cancer Institute Common Toxicity Criteria for Adverse Events,
EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-30,
ECOG PS: Eastern Cooperative Oncology Group performance status,
NCCN: National Comprehensive Cancer Network Guidelines for Adult Cancer, WHO: world health organization,
QoL: quality of life, KPS: Karnofsky Performance Scale, PNCV: peripheral nerve conduction velocity, NCV: nerve conduction velocity, MNCV: motor nerve conduction velocity, SNCV: sensory nerve conduction velocity, SNAPA: Sensory nerve action potential amplitude, NGF: nerve growth factor, SOD: superoxide dismutase, MDA: malondialdehyde, NRS: Numerical Rating Scale.

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