Flavonol 7-O-Glucoside Herbacitrin Inhibits HIV-1 Replication through Simultaneous Integrase and Reverse Transcriptase Inhibition

Figure 2

Effect of noncytotoxic concentrations of herbacitrin (1), gossypitrin (2), and quercetin (3) on HIV-1 replication in MT-4 (a) or MT-2 (b) cells cultivated in vitro. Compounds 1-3 were applied at 2.1 μM, AZT: azidothymidine (nucleoside reverse transcriptase inhibitor; positive control at 0.64 μM). Means are given in percentage of the virus control; the error bars show standard error of mean (SEM); statistically significant differences were evaluated as compared to the negative control: and : p<0.05 and 0.001, respectively, by means of one-way ANOVA followed by Bonferroni’s post hoc test, (P): p<0.05 by means of a planned comparison, involving compound 1 and the positive and negative controls only, by one-way ANOVA and Bonferroni’s post hoc test.

(a)

(b)