Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic β Cell Identity in db/db Mice
Effects of HRD on glucose metabolism. (a) The FBG in each group is presented as the mean ± SEM. The difference between the control and model groups was significant throughout the experiment (p < 0.0001); p < 0.05 for model versus LHRD at the second and seventh weeks; p < 0.05 for model versus HHRD from the second to eighth weeks; no difference was detected between the model and SAX groups. (b) An IPITT was conducted. Blood glucose level is shown as mean ±SEM. The significant gap between control and model existed (p< 0.0001). p < 0.01 for model versus HHRD at 120 min; p < 0.05 for model versus SAX at 60 min, 90 min, and 120 min. (c) The data are shown as the mean ± SEM. p < 0.0001 for control versus model at all time-points; p < 0.05 for model versus LHRD at 90 min and 120 min; p < 0.05 for model versus HHRD at 0 min and 90 min; p < 0.05 for model versus SAX at 90 min and 120 min. (d) The AUC in the IPGTT is shown as the mean ± SD. (e) The FINS is shown as the mean ± SEM. (F) The HOMA-IR is shown as the mean ± SD. n=5-8 mice in each group. represented p < 0.01 versus control group, represented p < 0.0001 versus control group, # represented p < 0.05 versus model group, ## represented p < 0.01 versus model group, ### represented p < 0.001 versus model group.
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