Review Article

Ethnopharmacology, Phytochemistry, and Pharmacology of the Genus Glehnia: A Systematic Review

Table 2

The chemical constituents isolated from G. littoralis.

ClassesCompound namePart of plantReferences

Phenylpropanoids(S)-Phenyllactic acid (1)Dried roots[19]
(S)-Phenyllactic acid methyl ester (2)Dried roots[19]
Caffeic acid (3)Dried root, dried underground parts[38, 39]
Chlorogenic acid (4)Dried root, dried underground parts[38, 39]
Ferulic acid (5)Dried root, dried underground parts[3840]
3-Methoxy-4-β-D-glucopyranosyloxypropiophenone (6)Dried underground parts, dried roots bark[39, 41]
4-[β-D-Apiofuranosyl-(1⟶6)-β-D-glucopyranosyloxy]-3-methoxypropiophenone (7)Dried root, dried underground parts[39, 42]
2-Methoxy-4-(1-propionyl) phenyl β-D-glucopyranoside (8)Fresh root and rhizome[43]
Syringin (9)Dried root, dried roots bark[41, 44]
Glehnilate (10)Dried underground parts[45]

CoumarinsUmbelliferone (11)Dried roots, dried roots and rhizomes[4648]
Esculetin (12)Dried root[49]
Umbelliferone 7-O-β-D-glucopyranoside (13)Fresh fruit, dried root[38, 50]
Scopoletin (14)Dried root and rhizome, dried root, dried underground parts[38, 39, 4648, 51, 52]
Scopolin (15)Dried root[38, 49]
Scopoletin-apiosyl-glucoside (16)Dried root[38]
Osthenol 7-O-β-D-gentibioside (17)Fresh fruit[50]
6-(3,3-Dimethylallyl)-7-hydroxycoumarin (18)Dried root[38]
6-(3,3-Dimethylallyl)-7-hydroxycoumarin-apiosyl-glucoside (19)Dried root[38]
6-(3,3-Dimethylallyl)-7-hydroxycoumarin-diglucoside (20)Dried root[38]
7-O-(3,3-Dimethylallyl) scopoletin (21)Dried root and rhizome[52]
(S)-Peucedanol 7-O-β-D-glucopyranoside (22)Fresh roots and rhizomes[53]
(S)-Peucedanol 3′-O-β-D-glucopyranoside (23)Fresh roots and rhizomes[53]
(R)-Peucedanol 3′-O-β-D-glucopyranoside (24)Fresh roots and rhizomes[53]
(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside (25)Fresh roots and rhizomes[53]
(S)-Peucedanol 3′-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (26)Fresh roots and rhizomes[53]
(S)-7-O-Methylpeucedanol 3′-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (27)Fresh roots and rhizomes[53]
(+)-cis-(3′S,4′S)-Diisobutyrylkhellactone (28)Whole plants[54]
3′-Senecioyl-4′-acetylkhellactone (29)Whole plants[54]
3′-Isovaleryl-4′-acetylkhellactone (30)Whole plants[54]
3′,4′-Disenecioylkhellactone (31)Whole plants[54]
3′-Isovaleryl-4′-senecioylkhellactone (32)Whole plants[54]
3′,4′-Diisobutyrylkhellactone (33)Whole plants[54]
Marmesin (34)Dried root and rhizome[52]
Rutaretin (35)Dried root[38]
Marmesin 4′-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (36)Fresh roots and rhizomes[53]
Marmesinin (37)Fresh and dried roots, dried underground parts, fresh fruit[39, 50, 53]
Leptophyllin (38)Dried root[38]
(3′R)-Hydroxymarmesin 4′-O-β-D-glucopyranoside (39)Fresh roots and rhizomes, dried roots and rhizomes, fresh fruit[39, 50, 53]
Oxymarmesinin 5′-O-β-D-glucopyranoside (40)Fresh fruit[50]
Leptophyllin-2-glucoside (41)Dried root[21]
Oxymarmesin 5′-O-β-D-glucopyranoside (42)Fresh roots and rhizomes, dried underground parts, fresh fruit[43, 50]
Psoralen (43)Dried root, dried underground parts, sliced roots, dried root and rhizome[38, 39, 51, 52, 55]
Xanthotoxol (44)Dried root, dried underground parts, dried root and rhizome[38, 39, 52]
Xanthotoxin (45)Dried root, sliced roots, dried root and rhizome[38, 40, 42, 48, 51, 52, 55]
Xanthotoxol 8-O-β-D-glucopyranoside (46)Fresh fruit[50]
Xanthotoxol-diglucoside (47)Dried root[38]
Xanthotoxol-triglucoside (48)Dried root[38]
8-Methoxy-5-hydroxypsoralen (49)Dried root[38]
Bergapten (50)Dried root, dried root and rhizomes, sliced roots[38, 40, 47, 48, 51, 52, 55]
5-Methoxy-8-hydroxypsoralen (51)Dried root[38]
Isoimpinellin (52)Dried root[38]
8-Methoxy-5-hydroxypsoralen-glucopyranoside (53)Dried root[38]
Bergaptol5-O-β-D-gentiobioside (54)Dried root, dried underground parts[39, 56]
Imperatorin (55)Dried root, sliced roots, dried root, and rhizomes[38, 42, 51, 52, 55]
8-(2-Hydroxy-3-methylbut-3-enoxy)-psoralen (56)Dried root[38]
4″-Hydroxyimperatorin (57)Dried root[38]
8-Geranyloxypsoralen (58)Dried roots and rhizomes, fresh roots and rhizomes[43, 52]
4″-Hydroxyrmyperatorin 4″-O-β-D-glucopyranoside (59)Fresh roots and rhizomes, dried underground parts[39, 53]
5″-Hydroxyimperatorin 5″-O-β-D-glucopyranoside (60)Fresh roots and rhizomes[53]
Prangenin (61)Dried root[38]
8-(1,1-Dimethylallyl)-5-hydroxypsorolen (62)Dried root and rhizome[52]
Alloisoimperatorin (63)Dried roots and rhizomes[52]
Byak-angelicol (64)Dried root[38]
Byak-angelicin (65)Dried root[38]
Phellopterin (66)Dried root[38, 57, 58]
Isoimperatorin (67)Dried root, dried underground parts, sliced roots, dried roots and rhizome[38, 39, 42, 46, 51, 52, 55, 59]
Cnidilin (68)Dried root and rhizome, dried root[38, 40, 52]
Isooxypeucedanin (69)Dried root[38]
Pabulenol (70)Dried root[38]
Oxypeucedanin hydrate (71)Dried root[38]
Oxypeucedanin (72)Dried root[38]
8-[(2E,5E)-7-Hydroxy-3,7-dimethylocta-2,5-dieny-loxy] psoralen (73)Fresh roots and rhizomes[43]
Bergaptin (74)Dried roots and rhizomes[52]
8-[(2E)-6-Oxo-3,7-dimethyloct-2-enyloxy] psoralen (75)Fresh roots and rhizomes[43]
Demethylsuberosin (76)Sliced roots[55]

Lignanoids(-)-Secoisolariciresinol (77)Dried underground parts[39]
(-)-Secoisolariciresinol 4-O-β-D-glucopyranoside (78)Dried root, dried underground parts[39, 49]
Glehlinoside G (79)Dried root[64]
Glehlinoside F (80)Dried root[61]
Glehlinoside E (81)Dried root[61]
Glehlinoside A (82)Dried underground parts[39]
Glehlinoside B (83)Dried underground parts[39]
Glehlinoside C (84)Dried root, dried underground parts[39, 49]
Citrusin A (85)Dried underground parts[39, 62]
Glehlinosides D (86)Dried root[63]
Glehlinosides H (87)Dried root[64]
3-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-1-(E)-propenyl)-2-methoxyphenoxy] propyl-β-D-glucopyranoside (88)Dried root[49]
Glehlinosides I (89)Dried root[64]
Glehlinoside J (90)Dried root[49, 64]
2,3E-2,3-Dihydro-2-(3′-methoxy-4′-hydroxyphenyl)-3-hydroxymethyl-5-(3″-hydroxypropeyl)-7-O-β-D-glucopyranosyl-1-benzo[b] furan (91)Dried root[49]
(7R,8S)-dehydrodiconiferylalcohol-4,9-di-O-β-D-glucopyranoside (92)Dried root[56, 60]

FlavonoidsQuercetin (93)Dried underground parts[39]
Isoquercetin (94)Dried underground parts[39]
Rutin (95)Dried underground parts[39]

Organic acids and derivativesSalicylic acid (96)Dried roots[19, 40]
Vanillic acid (97)Dried root, dried underground parts[3840]
4-O-β-D-Glucopyranosyl vanillic acid (98)Dried root[42]
Vanillic acid 4-O-β-D-glucopyranoside (99)Dried root[44]
Protocatechuic acid methyl ester (100)Dried root[49]
1-O-Vanilloyl-β-D-glucose (101)Dried root[42]
Vanillic acid 1-O-[β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside] ester (102)Dried root[19, 42]
Dibutyl phthalate (103)Dried roots[19]
Tetracosanoic acid (104)Dried roots of three-year-old[65]
9-Hydroxystearic acid (105)Dried roots[19]
Glehlinosiden (106)Dried roots bark[41]
Linoleic acid (107)Dried root and rhizome[51]
Nonadecanoic acid (108)Dried roots of three-year-old[65]
1-Linoloyl-3-palmitoylglycerol (109)Dried roots[46]

Terpenoids(−)-Angelicoidenol [(2R,5S)-bornane-2,5-diol] 2-O-β-D-glucopyranoside (110)Fresh roots and rhizomes[66]
(−)-Angelicoidenol 2-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (111)Fresh roots and rhizomes[66]
(2R,6S)-Bornane-2,6-diol 2-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (112)Fresh roots and rhizomes[66]
(4R)-p-Menth-1-ene-7,8-diol 8-O-β-D-glucopyranoside (113)Fresh fruit[50]
(4R)-p-Menth-1-ene-7,8-diol 8-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (114)Fresh roots and rhizomes[66]
trans-p-Menth-2-ene-1,7,8-triol (115)Fresh fruit[50]
cis-p-Menth-2-ene-1,7,8-triol (116)Fresh fruit[50]
(2R)-Bornane-2,9-diol 2-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (117)Fresh roots and rhizomes[66]
(+)-Angelicoidenol [(2S,5R)-bornane-2,5-diol] 2-O-β-D-glucopyranoside (118)Fresh roots and rhizomes[66]
trans-p-Menth-2-ene-1α,2β,8-triol (119)Fresh fruit[50]
(4S)-p-Menth-1-ene-7,8-diol 8-O-β-D-apiofuranosyl-(1⟶6)-β-D-glucopyranoside (120)Fresh roots and rhizomes[66]
(5β,10α)-Lasidiol angelate (121)Dried root[47]
Botulin (122)Dried root[59]
Lupeol (123)Dried root[59]

PolyacetylenesFalcarindiol (124)Dried root, sliced roots, dried root, and rhizome[19, 42, 46, 51, 55, 67]
(3R,9Z)-Heptadeca-1,9-dien-4,6-diyn-3-ol (125)Dried roots[19]
(8E)-1,8-Heptadecadiene-4,6-diyne-3,10-diol (126)Dried root, dried root and rhizome[19, 40, 42, 51, 59]
(3S,9Z)-Heptadeca-1,9-dien-4,6-diyn-3-ol (127)Dried root, dried root and rhizome[42, 46, 47, 51, 59]
Ginsenoyne K (128)Dried root[42]
(10E)1,10-Heptadecadiene-4,6-diyne-3,8,9-triol (129)Dried root[67]
Falcaindiol (130)Air- dried plant[68, 69]
Panaxydiol (131)Air- dried plant[69]
(9Z)1,9-Heptadecadiene-4,6-diyne-3,8,11-triol (132)Dried root[67]

Steroidsβ-Sitosterol (133)Dried roots[42, 46, 59]
Daucosterol (134)Dried root[59]
Stigmasterol (135)Dried roots of three-year-old[65]
Cerevisterol (136)Dried roots of three-year-old[65]

Nitrogen compounds(3S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid (137)Dried roots[19]
(1S,3S)-1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (138)Dried roots[19]
(1R,3S)-1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (139)Dried roots[19]
Uridine (140)Dried underground parts[39]
Adenosine (141)Dried root, dried underground parts, fresh fruit[38, 39, 42, 50]
9,9a-Dihydro-naphtho [2, 3-c] isoxazol-3(1H)-one (142)Root[70]
Arginine (143)Dried roots[71]
5′-Methylthioadenosine (144)Dried roots[72]
L-Tryptophan (145)Dried roots[72]

Other chemical constituentsCatechol (146)Dried roots[19]
4-Hydroxyphenethyl alcohol (147)Dried roots[19]
Icariside F2 (148)Dried root, fresh fruit[42, 44, 50]
Icariside D (149)Dried root[44]
Benzyl β-D-glucopyranoside (150)Fresh fruit[50]
Phenethyl β-D-glucopyranoside (151)Fresh fruit[50]
1-β-D-Glucosyloxy-2-(3-methoxy-4-hydroxyphenyl) propane-1,3-diol (152)Air-dried plant[68]
2-Methyl-3-buten-2-ol β-D-apiofuranosyl-(1⟶6)- β-D-glucopyranoside (153)Fresh root and rhizome[43]
2-Methyl-3-buten-2-ol β-D-glucopyranoside (154)Fresh fruit[50]
Isopropyl β-D-glucopyranoside (155)Fresh fruit[50]
Ethyl β-D-glucopyranoside (156)Fresh fruit[50]
Butane-2,3-diol 2-O-β-D-glucopyranoside (157)Fresh fruit[50]
Isopropyl β-D-apiofranosyl-(1⟶6)-β-D-glucopyranoside (158)Fresh fruit[50]
3,7-Dimethyloct-3(10)-ene-1,2,6,7-tetrol (159)Fresh fruit[50]
(2S,6Z)-3,7-Di-methyloct-3(10)-ene-1,2,6,7-tetrol 1-O-β-D-glucopyranoside (160)Fresh fruit[50]
6-Carboxyethyl-7-methoxy-5-hydroxybenzofuran 5-O-β-D-glucopyranoside (161)Fresh fruit[50]
Cnidioside A (162)Fresh root and rhizome[43]
Sec-O-glucosylhamaudol (163)Dried root[49]
Corchoionoside A (164)Fresh fruit[50]
1,2-Di-O-vanilloyl-β-D-glucopyranoside (165)Dried roots[5]
2-Deoxy-D-ribitol (166)Fresh fruit[50]
(3R)-2-Hydroxymethylbutane-1,2,3,4-tetrol (167)Fresh fruit[50]
D-Threitol (168)Fresh fruit[50]
Erythritol (169)Fresh fruit[50]
n-Butyl α-D-fructofuranoside (170)Dried root[43]
5-Methoxyfurfural (171)Dried roots of three-year-old[65]
(2E,4E)-Deca-2,4-dienal (172)Dried roots[73]
(E)-Oct-2-en-1-ol (173)Dried roots[73]
1,6-Di-O-vanilloyl-β-D-glucopyranoside (174)Dried roots[5]