Huangqi Shengmai Yin Protects against Radiation-Induced Cardiac Fibrosis Injury by Regulating the TGF-β1/Smads and MMPs
Figure 2
Changes to myocardial collagen in rat models. (a) Masson staining was performed at day 1 and weeks 1, 2, 4, and 6 after rats were irradiated with 25 Gy X-rays, revealing changes to the myocardial collagen of irradiated rats. Magnification ×400. (b) Low-dose (0.31 ml/d, LDG), medium dose (0.62 ml/d, MDG), and high dose (1.24 ml/d, HDG) of HSY were given daily to irradiated rats. Masson staining was performed after four weeks of continuous intervention to observe the effect of HSY on myocardial collagen of RIHD. Magnification ×400. (c) Collagen volume fraction (CVF) in myocardial tissue was calculated in irradiated rats. p < 0.01 versus 1d. (d) Collagen volume fraction (CVF) in myocardial tissue was calculated in HSY intervention rats. ## p < 0.01 versus Con; p < 0.01 versus 25 Gy.