Research Article

Network Pharmacology Analysis of Damnacanthus indicus C.F.Gaertn in Gene-Phenotype

Table 1

Identification of direct targets of resveratrol using BATMAN-TCM Searched.

CompoundPredicted targets [Gene Symbol] ranked according to the decreasing (score)

DamncanthalThis compound doesn’t have any potential target with score larger than 20.
NordamnacanthalESR1(23.00)
7-HydroxyaloinThis compound doesn’t have any potential target with score larger than 20.
18-Nordehydroabietan-4alpha-OlS1PR5(48.000)ESR2(48.000)ESR1(48.000)NR1I2(48.000)
Nor-KetoagarofuranAR(48.000)
2-BenzylxanthopurpurinESR1(80.882)HSD17B1(23.000)TFAP2C(22.373)TOX3(22.373)TGFB1(22.373)
MED1(22.373)NKX3-1(22.373)ESR2(22.373)SHH(22.373)LEF1(22.373)
FGFR2(22.373)PGR(22.373)WNT4(22.373)AREG(22.373)GPER1(22.373)
WNT5A(22.373)SOX9(22.373)VDR(22.373)TRIM24(22.373)
KadsudilactoneCHRM3(80.882)CHRM1(80.882)CHRM2(80.882)PGR(48.000)AR(48.000)
NR3C2(48.000)ARFGEF2(22.373)DOCK5(22.373)NTSR1(22.373)CHRM5(22.373)
GNA15(22.373)P2RX1(22.373)DOCK4(22.373)MAP2K1(22.373)CHRM4(22.373)
DamnacanthalThis compound doesn’t have any potential target with score larger than 20.
JuzunalThis compound doesn’t have any potential target with score larger than 20.
DigiferrugineolCHRM3(23.000)CHRM1(23.000)CHRM2(23.000)CHRM4(23.000)
DamsinPGR(80.882)AR(80.882)CYP19A1(80.882)NR3C2(80.882)WNT4(55.444)
CACNA1I(23.000)CACNA1G(23.000)TNFSF11(22.373)COL5A1(22.373)NOX1(22.373)
PHB(22.373)MED1(22.373)NKX3-1(22.373)ESR1(22.373)NEDD4(22.373)
SHBG(22.373)SERPINB3(22.373)FOXP3(22.373)C5(22.373)SRC(22.373)
STAP1(22.373)TGFB2(22.373)MMP28(22.373)UBR5(22.373)IL10(22.373)
NR1I3(22.373)TNFAIP3(22.373)ALDH1A1(22.373)IL4(22.373)TSPO(22.373)
CX3CR1(22.373)CD34(22.373)S100A9(22.373)PDGFB(22.373)VDR(22.373)
NorjuzunalESR1(23.000)