Mistletoe-Based Drugs Work in Synergy with Radio-Chemotherapy in the Treatment of Glioma In Vitro and In Vivo in Glioblastoma Bearing Mice

Table 1

IC₅₀-values [ng/ml of ML] for ISCADOR Qu, Aviscumine, and native ML-1 in glioma and nonneoplastic cell lines. Cell density was measured by crystal violet. IC₅₀-values were calculated from the mean of at least three independent experiments (del: deleted, mut: mutated, WT: wild type, and n.d.: not determined).

Cell line				IC50 24 h			IC50 48 h
	p53	PTEN	p14/16	ISC Qu	Avi	ML-1	ISC Qu	Avi	ML-1
LNT-229	WT	WT	del	37.09	95,60	>240	10.50	17.78	29.73
LN-308	del	mut	WT	139.72	>240	>240	83.13	>240	>240
LN-319	WT	mut	WT	71.36	>240	>240	24.64	18.23	27.95
U87MG	WT	del	del	140.60	>240	>240	81.03	>240	>240
T98G	mut	mut	del	101.19	>240	>240	51.24	158.81	113.11
MZ-18	mut	n.d.	n.d.	35.45	>240	>240	11.56	10.94	9.97
SMA-560	n.d.	n.d.	n.d.	35.70	10.23	19.25	17.31	2.69	8.25
SV-GA				65.95	>240	>240	2.36	1.37	1.02
HBVP				28.86	>240	58.37	4.85	23.59	5.01
hCMEC/D3				>240	>240	>240	27.92	105.12	42.02