Intestinal Absorption Profile of Three Polygala Oligosaccharide Esters in Polygalae Radix and the Effects of Other Components in Polygalae Radix on Their Absorption
Table 3
Absorption parameters of SA5, SA6, and DISS in PRE in the intestines of rats (; n = 5).
Compound
Concentration (mg/ml)
(μg·cm−2·min−1)
(×10−5cm/s)
(%)
SA5
0.025
0.020 ± 0.0013
1.34 ± 0.092
5.44 ± 0.42
0.050
0.048 ± 0.0011
1.61 ± 0.035
6.60 ± 0.17
0.075
0.077 ± 0.0030
1.71 ± 0.067
6.98 ± 0.25
SA6
0.043
0.029 ± 0.0020
1.12 ± 0.077
4.46 ± 0.33
0.086
0.066 ± 0.0080
1.27 ± 0.093
5.21 ± 0.12
0.130
0.100 ± 0.0067
1.29 ± 0.086
5.34 ± 0.04
DISS
0.099
0.036 ± 0.0019
0.61 ± 0.0033
2.55 ± 0.03
0.198
0.075 ± 0.0013
0.63 ± 0.011
2.71 ± 0.12
0.296
0.109 ± 0.010
0.61 ± 0.057
2.54 ± 0.19
< 0.01 and < 0.05, compared with low dose; < 0.01 and < 0.05, compared with medium dose.