Research Article

Intestinal Absorption Profile of Three Polygala Oligosaccharide Esters in Polygalae Radix and the Effects of Other Components in Polygalae Radix on Their Absorption

Table 3

Absorption parameters of SA5, SA6, and DISS in PRE in the intestines of rats (; n = 5).

CompoundConcentration (mg/ml) (μg·cm−2·min−1) (×10−5cm/s) (%)

SA50.0250.020 ± 0.00131.34 ± 0.0925.44 ± 0.42
0.0500.048 ± 0.00111.61 ± 0.0356.60 ± 0.17
0.0750.077 ± 0.00301.71 ± 0.0676.98 ± 0.25
SA60.0430.029 ± 0.00201.12 ± 0.0774.46 ± 0.33
0.0860.066 ± 0.00801.27 ± 0.0935.21 ± 0.12
0.1300.100 ± 0.00671.29 ± 0.0865.34 ± 0.04
DISS0.0990.036 ± 0.00190.61 ± 0.00332.55 ± 0.03
0.1980.075 ± 0.00130.63 ± 0.0112.71 ± 0.12
0.2960.109 ± 0.010 0.61 ± 0.0572.54 ± 0.19

< 0.01 and < 0.05, compared with low dose; < 0.01 and < 0.05, compared with medium dose.