Phytochemical Analysis and Toxicity Study of Aristolochia paucinervis Rhizomes Decoction Used in Moroccan Alternative Medicine: Histopathological and Biochemical Profiles
Table 3
Lesion scores of the kidney for all groups analyzed using ANOVA test (subacute toxicity).
Histopathology of kidney
Histopathology scores of observation
ANOVA test for global comparison of organ lesions among groups
(mean) per each group
control group
group 1
group 2
group 3
Tubular necrosis
0
0
0.11±0.01
0.25±0.05
0.006
Hyaline necrosis
0
0
0.05±0.05
0.19±0.04
0.04
Coagulation necrosis
0
0
0
0.22±0.17
0.31
Inflammatory infiltrate
0
0
0.35±0.15
0.60±0.10
0.02
Extended coagulation
0
0
0
0
1
Altered tissue architecture
0
0
0
0
1
Cell vacuolization
0
0
0
0.25±0.25
0.47
Tubular degeneration
0
0
0.20±0.20
0.31±0.19
0.28
Cell congestion
0
0
0.10±0.03
0.17±0.02
0.04
Tubular atrophy
0
0
0
0
1
Interstitial fibrosis
0
0
0
0
1
Vascular dilation
0
0
0
0.16±0.03
0.006
Control: normal diet; group 1: normal diet + 0.5 g/kg/day extract; group 2: normal diet + 1 g/kg/day extract; group 3: normal diet + 1.5 g/kg/day extract. : significant at 5% level.
