Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 5

Research Article

Phytochemical Analysis and Toxicity Study of Aristolochia paucinervis Rhizomes Decoction Used in Moroccan Alternative Medicine: Histopathological and Biochemical Profiles

Table 5

Lesion scores of the liver for all groups analyzed using ANOVA test (subacute toxicity).

Histopathology of liverHistopathology scores of observation (mean) per each groupANOVA test for global comparison of organ lesions among groups
control groupgroup 1group 2group 3

Hepatocellular necrosis00.001±0.00070.45±0.050.35±0.050.002
Lobular necrosis000.13±0.0100.00
Altered tissue architecture00001
Cell vacuolization000.02±0.020.25±0.050.008
Cell congestion00001
Inflammatory infiltrate00.01±0.010.17±0.120.5±0.100.03
Dilatation of sinusoids00001
Kupffer cell hypertrophy00001
Hepatic steatosis00001
Haemorrhagic foci00001
Disruption of blood vessel00001

Control: normal diet; group 1: normal diet + 0.5 g/kg/day extract; group 2: normal diet + 1 g/kg/day extract; group 3: normal diet + 1.5 g/kg/day extract.
: significant at 5% level.

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