Phytochemical Analysis and Toxicity Study of Aristolochia paucinervis Rhizomes Decoction Used in Moroccan Alternative Medicine: Histopathological and Biochemical Profiles
Table 5
Lesion scores of the liver for all groups analyzed using ANOVA test (subacute toxicity).
Histopathology of liver
Histopathology scores of observation (mean) per each group
ANOVA test for global comparison of organ lesions among groups
control group
group 1
group 2
group 3
Hepatocellular necrosis
0
0.001±0.0007
0.45±0.05
0.35±0.05
0.002
Lobular necrosis
0
0
0.13±0.01
0
0.00
Altered tissue architecture
0
0
0
0
1
Cell vacuolization
0
0
0.02±0.02
0.25±0.05
0.008
Cell congestion
0
0
0
0
1
Inflammatory infiltrate
0
0.01±0.01
0.17±0.12
0.5±0.10
0.03
Dilatation of sinusoids
0
0
0
0
1
Kupffer cell hypertrophy
0
0
0
0
1
Hepatic steatosis
0
0
0
0
1
Cholestasis
0
0
0.17±0.17
0.35±0.05
0.13
Haemorrhagic foci
0
0
0
0
1
Disruption of blood vessel
0
0
0
0
1
Control: normal diet; group 1: normal diet + 0.5 g/kg/day extract; group 2: normal diet + 1 g/kg/day extract; group 3: normal diet + 1.5 g/kg/day extract. : significant at 5% level.
