Citrus Alkaline Extract Delayed the Progression of Pulmonary Fibrosis by Inhibiting p38/NF-B Signaling Pathway-Induced Cell Apoptosis

Figure 2

Effects of CAE on histopathologic change of lungs by BLM-induced pulmonary fibrosis mice. (a) Lung sections were stained with HE and Masson, and photographs were taken at magnifications of 200x, respectively. (b) Effects of CAE on the alveolitis score of lung. (c) Effects of CAE on the fibrosis score of lung. Normal: normal group, water; BLM: model group, BLM+water; L: CAE-16 group, BLM+ CAE at a dose of 16mg/kg once per day; M: CAE-32 group, BLM+ CAE at a dose of 32mg/kg once per day; H: CAE-64 group, BLM+ CAE at a dose of 64mg/kg once per day; Prednisone: prednisone group, BLM+ prednisone at a dose of 6mg/kg once per day; Pirfenidone: pirfenidone group, BLM+ prednisone at a dose of 100mg/kg once per day. All data are expressed as mean ±SD (n=6), ^##P < 0.01 versus Normal group; versus BLM group; versus BLM group.

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