Citrus Alkaline Extract Delayed the Progression of Pulmonary Fibrosis by Inhibiting p38/NF-B Signaling Pathway-Induced Cell Apoptosis

Figure 3

Effects of CAE on collagen content change of BLM-induced lung injury in mice. (a) The expressions of collagen I and collagen III in the lung tissues were measured by immunohistochemical assay (Magnification, 200x). (b) The quantitative result of collagen I. (c) The quantitative result of collagen III. (d) The expressions of HYP in the lung tissues were detected by ELISA method. Normal: normal group, water; BLM: model group, BLM+water; L: CAE-16 group, BLM+ CAE at a dose of 16mg/kg once per day; M: CAE-32 group, BLM+ CAE at a dose of 32mg/kg once per day; H: CAE-64 group, BLM+ CAE at a dose of 64mg/kg once per day; Prednisone: prednisone group, BLM+ prednisone at a dose of 6mg/kg once per day; Pirfenidone: pirfenidone group, BLM+ prednisone at a dose of 100mg/kg once per day. All data are expressed as mean ±SD (n=6), versus normal group; versus BLM group; versus BLM group.

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