Citrus Alkaline Extract Delayed the Progression of Pulmonary Fibrosis by Inhibiting p38/NF-B Signaling Pathway-Induced Cell Apoptosis

Figure 7

Effects of CAE on the expression of p-p38 and NF-B in pulmonary tissue of BLM-induced pulmonary fibrosis mice. (a) The expressions of p-p38 in the lung tissues were recorded by Western Blot. (b) The expressions of NF-B in the lung tissues were tested by immune-fluorescent methods (Magnification, 200x). (c) The quantitative result of p-p38. All data are expressed as mean ±SD (n=3), versus normal group; versus BLM group. (d) The quantitative result of NF-B. All data are expressed as mean ±SD (n=6), versus normal group; versus BLM group. Normal: normal group, water; BLM: model group, BLM+water; L: CAE-16 group, BLM+ CAE at a dose of 16mg/kg once per day; M: CAE-32 group, BLM+ CAE at a dose of 32mg/kg once per day; H: CAE-64 group, BLM+ CAE at a dose of 64mg/kg once per day; Prednisone: prednisone group, BLM+ prednisone at a dose of 6mg/kg once per day; Pirfenidone: pirfenidone group, BLM+ prednisone at a dose of 100mg/kg once per day.

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