Compound Phyllanthus urinaria L Inhibits HBV-Related HCC through HBx-SHH Pathway Axis Inactivation

Figure 2

CP could inhibit proliferation of HepG2-HBx cells. Being treated for 24 h (a, b) and 48 h (c, d), the proliferation was measured by MTT. IC₅₀ of the CP was calculated using the Graphpad prism soft (e). Then we measured the proliferation of HepG2-HBx cells administrated with CP or cyclopamine (70μM) for 48 h (f). ^ηηηP < 0.001, compared with HepG2-HBx cells administration with 0 μg/ml. < 0.001, compared with the group of HepG2-NC. ^###P < 0.001, compared with the group of HepG2-HBx.

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