The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury
Table 2
The distributions of allele and genotype frequencies of all fifteen SNPs.
Gene
dbSNP
Allele
Genotype
Allele
ATDILI (n, %)
Non-ATDILI (n, %)
OR (95% CI)
ATDILI
Non-ATDIH
1/2
1/2
11/12/22
11/12/22
TGFBRAP1
rs17687727
G > A
46/188
171/1083
1.55 (1.08–2.22)
0.016
0.883
4/38/75
11/149/467
0.055
rs75725426
A > G
27/205
140/1116
1.05 (0.67–1.62)
0.827
0.096
2/23/91
12/116/500
0.936
rs2241797
T > C
64/170
340/912
1.01 (0.73–1.38)
0.951
0.578
8/48/61
50/240/336
0.821
rs12476720
A > G
113/123
622/634
0.93 (0.70–1.23)
0.643
1.000
28/57/33
153/316/159
0.832
TGFBR2
rs1835538
G > A
29/207
188/1068
0.79 (0.52–1.20)
0.283
0.638
2/25/91
12/164/452
0.512
rs9881945
G > T
36/200
180/1074
1.07 (0.72–1.58)
0.718
0.744
3/30/85
14/152/461
0.937
rs4522809
A > G
69/167
382/868
0.93 (0.69–1.27)
0.685
0.924
6/57/55
59/264/302
0.216
rs11924422
C > A
69/167
383/869
0.93 (0.69–1.27)
0.678
0.258
9/51/58
52/279/295
0.912
rs12493607
C > G
78/158
412/838
1.00 (0.74–1.35)
0.978
0.651
11/56/51
65/282/278
0.874
rs1808602
A > G
102/134
575/677
0.89 (0.67–1.18)
0.443
0.809
19/64/35
130/315/181
0.497
rs114342639
G > T
46/190
260/994
0.92 (0.65–1.31)
0.664
0.903
4/38/76
26/208/393
0.897
rs3773644
C > T
88/148
500/754
0.89 (0.67–1.19)
0.456
0.454
18/52/48
95/310/222
0.508
rs3773652
G > A
123/113
602/648
1.17 (0.88–1.54)
0.264
0.575
32/59/27
141/320/164
0.509
rs2043136
A > G
17/101
102/524
0.94 (0.71–1.25)
0.680
0.033
17/64/37
102/334/190
0.874
rs876688
G > A
66/170
297/959
1.25 (0.91–1.71)
0.155
0.438
11/44/63
31/235/362
0.156
: value was calculated using logistic regression analysis. : value of Hardy–Weinberg equilibrium. HWE was assessed by the χ2 goodness-of-fit test based on the genotype distributions in this study. The significance of bold in the table means value < 0.05. “1” designates the mutant allele and “2” designates the wild allele; 11 = mutant homozygote; 12 = heterozygote; 22 = wild homozygote.
