Eucommia ulmoides Oliv. Leaf Extract Improves Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats by Protecting Endothelial Function and Ameliorating Hypothalamic-Pituitary-Gonadal Axis Function

Figure 6

EULE increased Akt phosphorylation and suppressed JNK and STAT3 phosphorylation in diabetic rats. (a) Western blot showing the effects of EULE on the expression of Akt, phosphor-Akt, STAT3, phosphor-STAT3, JNK, and phosphor-JNK protein in diabetic rats. (b) Relative expression levels of Akt normalized to GAPDH expression. (c) Phosphorylated Akt levels normalized to total Akt levels. (d) Phosphorylated JNK levels normalized to total JNK levels. (e) Phosphorylated STAT3 levels normalized to total STAT3 levels. The data are presented as the mean ± SEM. p < 0.05 and p < 0.01 versus the control group; # p < 0.05 and ## p < 0.01 versus the DM group (n = 10 in each group).

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