Granule of BU-XIN RUAN-MAI Attenuates the Patients’ Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling

Figure 1

Granule of BU-XIN RUAN-MAI improves the oxidation and inflammation in myocardial ischemia of rats caused by isoprenaline. (a) Granule of BU-XIN RUAN-MAI attenuated myocardial cell injury in rats demonstrated by H&E staining. (b) The effects of Granule of BU-XIN RUAN-MAI on the content of MDA (μmol/L), SOD (U/mL), Na+/K + -ATPase (μmol/g protein), and cAMP (pmol/L); data shown are mean ± SD; versus the normal group (sham) and versus the model group (ISO). (c) Granule of BU-XIN RUAN-MAI significantly enhanced the PPARα protein expression analyzed by Western blot, and (d) the corresponding semi-quantitative analysis was based on optical density with ImageJ software; data shown are mean ± SD; versus the sham group and versus the model group. (e) Granule of BU-XIN RUAN-MAI significantly increased the PPARα mRNA expression determined by real-time PCR; data shown are mean ± SD; versus the sham group and versus the model group. (f, g, h) Granule of BU-XIN RUAN-MAI elevated the content of IL-6, IL-1β, and TNF-α detected by ELISA; data shown are mean ± SD; versus the sham group and versus the model group. (i, j, k) Granule of BU-XIN RUAN-MAI enhanced the IL-6, IL-1β, and TNF-α mRNA expressions analyzed by real-time PCR; data shown are mean ± SD; versus the sham group and versus the model group. The data are representative of three independent experiments.

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