Granule of BU-XIN RUAN-MAI Attenuates the Patients’ Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling

<table class="table-group" id="tab8"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Group</td><td class="align_center">Number of cases</td><td class="align_center">Stage</td><td class="align_center">D-Dimer</td><td class="align_center">Fibrinogen</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left" rowspan="2">Placebo</td><td class="align_center">20</td><td class="align_center">Pretreatment</td><td class="align_center">2.03 ± 1.12</td><td class="align_center">3.97 ± 1.13</td></tr><tr><td class="align_center">20</td><td class="align_center">Posttreatment</td><td class="align_center">1.23 ± 0.86<sup>#</sup></td><td class="align_center">2.57 ± 1.27<sup>#</sup></td></tr><tr><td class="align_left" rowspan="2">Granule of BU-XIN RUAN-MAI</td><td class="align_center">20</td><td class="align_center">Pretreatment</td><td class="align_center">2.09 ± 1.08</td><td class="align_center">4.01 ± 1.22</td></tr><tr><td class="align_center">20</td><td class="align_center">Posttreatment</td><td class="align_center">0.66 ± 0.42<sup>#Δ</sup></td><td class="align_center">1.83 ± 0.68<sup>#Δ</sup></td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>There was no significant difference in patients’ coagulation indicator (D-Dimer and fibrinogen) contents between the placebo and Granule of BU-XIN RUAN-MAI group before treatment was administrated (<span class="nowrap"><svg height="9.2729pt" id="M28" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 44.8393 9.2729" width="44.8393pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 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602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg>).</span> <svg height="12.1645pt" id="M29" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.5275 49.7858 12.1645" width="49.7858pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.946,0)"><path d="M600 480C600 590 528 650 384 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466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.311,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> versus the pretreatment patients in the placebo or Granule of BU-XIN RUAN-MAI group; <svg height="12.5572pt" id="M30" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.9202 51.3111 12.5572" width="51.3111pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M610 0V27L347 666L316 657L46 26V0H610ZM504 54H116L310 537L504 54Z"></path></g><g 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d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,44.837,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> versus the posttreatment patients in the placebo group.<br/></div></td></tr></table>

<div>Effect of Granule of BU-XIN RUAN-MAI on indicators of patients’ coagulation.</div>

Evidence-Based Complementary and Alternative Medicine

tab8

Table 8

Table 8: Granule of BU-XIN RUAN-MAI Attenuates the Patients’ Angina Pectoris of Coronary Heart Disease via Regulating miR-542-3p/GABARAP Signaling 