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Evidence-Based Complementary and Alternative Medicine
Volume 2019, Article ID 1825750, 14 pages
https://doi.org/10.1155/2019/1825750
Review Article

Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials

Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China

Correspondence should be addressed to Fengmei Lian; moc.uhos@565mfl and Tong Xiao-lin; moc.361.piv@niloaixgnot

De Jin and Jiaxing Tian contributed equally to this work.

Received 31 October 2018; Revised 29 January 2019; Accepted 7 March 2019; Published 6 May 2019

Academic Editor: Laura De Martino

Copyright © 2019 De Jin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Wang, P. Gao, M. Zhang et al., “Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013,” Journal of the American Medical Association, vol. 317, no. 24, pp. 2515–2523, 2017. View at Publisher · View at Google Scholar
  2. W. T. Cade, “Diabetes-related microvascular and macrovascular diseases in the physical therapy setting,” Physical Therapy in Sport, vol. 88, no. 11, pp. 1322–1335, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. R. W. Grant and M. S. Kirkman, “Trends in the evidence level for the american diabetes association's ‘standards of medical care in diabetes’ from 2005 to 2014,” Diabetes Care, vol. 38, no. 1, pp. 6–8, 2015. View at Publisher · View at Google Scholar
  4. UK Prospective Diabetes Study (UKPDS) Group, “Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33),” The Lancet, vol. 352, no. 9131, pp. 837–853, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. S. E. Inzucchi, R. M. Bergenstal, J. B. Buse et al., “Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the american diabetes association and the european association for the study of diabetes,” Diabetes Care, vol. 38, no. 1, pp. 140–149, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. P. H. Marathe, H. X. Gao, and K. L. Close, “American diabetes association standards of medical care in diabetes 2017,” Journal of Diabetes, vol. 9, no. 4, pp. 320–324, 2017. View at Publisher · View at Google Scholar
  7. M. N. Cook, C. J. Girman, P. P. Stein, and C. M. Alexander, “Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care,” Diabetic Medicine, vol. 24, no. 4, pp. 350–358, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Lian, J. Tian, X. Chen et al., “The efficacy and safety of Chinese herbal medicine Jinlida as add-on medication in type 2 diabetes patients ineffectively managed by metformin monotherapy: a double-blind, randomized, placebo-controlled, multicenter trial,” PLoS ONE, vol. 10, no. 6, Article ID e0130550, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. X. L. Tong, S. T. Wu, F. M. Lian et al., “The safety and effectiveness of TM81, a Chinese herbal medicine, in the treatment of type 2 diabetes: a randomized double-blind placebo-controlled trial,” Diabetes, Obesity and Metabolism, vol. 15, no. 5, pp. 448–454, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Ji, X. Tong, H. Wang et al., “Efficacy and safety of traditional Chinese medicine for diabetes: a double-blind, randomised, controlled trial,” PLoS ONE, vol. 8, no. 2, Article ID e56703, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Zhang, X. Li, W. D. Liu et al., “Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine,” Journal of Clinical Endocrinology & Metabolism, vol. 93, no. 7, p. 2559, 2008. View at Google Scholar
  12. C. R. Cederroth, M. Vinciguerra, A. Gjinovci et al., “Dietary phytoestrogens activate AMP-Activated protein kinase with improvement in lipid and glucose metabolism,” Diabetes, vol. 57, no. 5, pp. 1176–1185, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. S. P. Li, G. H. Zhang, Q. Zeng et al., “Hypoglycemic activity of polysaccharide, with antioxidation, isolated from cultured Cordyceps mycelia,” Phytomedicine, vol. 13, no. 6, pp. 428–433, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-H. Jung, H.-M. Seog, I.-W. Choi, H.-D. Choi, and H.-Y. Cho, “Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats,” Journal of Ethnopharmacology, vol. 98, no. 3, pp. 245–250, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M.-P. Lu, R. Wang, X. Song, X. Wang, L. Wu, and Q. H. Meng, “Modulation of methylglyoxal and glutathione by soybean isoflavones in mild streptozotocin-induced diabetic rats,” Nutrition, Metabolism & Cardiovascular Diseases, vol. 18, no. 9, pp. 618–623, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. H. S. Zhen, J. Liang, and F. Zhou, “Studies on anti-hyperglycemic effect of ethanolic extracts from gymnema sylvestre(Retz.)schult,” Chinese Journal of Experimental Traditional Medical Formulae, 2007. View at Google Scholar
  17. H. Cao, M. M. Polansky, and R. A. Anderson, “Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes,” Archives of Biochemistry and Biophysics, vol. 459, no. 2, pp. 214–222, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Qin, M. Nagasaki, M. Ren, G. Bajotto, Y. Oshida, and Y. Sato, “Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats,” Diabetes Research and Clinical Practice, vol. 62, no. 3, pp. 139–148, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. J. P. Liu, M. Zhang, W. Y. Wang, and S. Grimsgaard, “Chinese herbal medicines for type 2 diabetes mellitus,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD003642, 2004. View at Google Scholar · View at Scopus
  20. F. De Vegt, J. M. Dekker, C. D. A. Stehouwer, G. Nijpels, L. M. Bouter, and R. J. Heine, “The 1997 american diabetes association criteria versus the 1985 world health organization criteria for the diagnosis of abnormal glucose tolerance: poor agreement in the hoorn study,” Diabetes Care, vol. 21, no. 10, pp. 1686–1690, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Godlee, “The cochrane collaboration: deserves the support of doctors and governments,” British Medical Journal, vol. 309, no. 6960, pp. 969-970, 1994. View at Publisher · View at Google Scholar · View at Scopus
  22. T. xiao-lin, F. Ni-Qing Lian et al., “Multi-center randomized controlled and double blind trial of Tang-min-ling pill s in the treatmen tof type 2 diabetes mellitus,” The Chinese Journal of Clinical Pharmacology, vol. 25, no. 02, pp. 104–108, 2009. View at Google Scholar
  23. F. Lian, L. Yao, X. Sun, D. Xiang, X. Xiao, and X. Tong, “The combined Tian Qi Jiangtang capsule and metformin treatment in patients with type 2 diabetes mellitus: a randomized, parallel-group, muiticenter, double-blind and prospective study,” Chinese Journal of Diabetes, vol. 19, no. 08, pp. 600–602, 2011. View at Google Scholar
  24. X. L. Tong, S. T. Wu, F. M. Lian et al., “The safety and effectiveness of TM81, a Chinese herbal medicine, in the treatment of type 2 diabetes: a randomized double-blind placebo-controlled trial,” Diabetes Obesity Metabolism, vol. 15, no. 5, pp. 448–454, 2013. View at Publisher · View at Google Scholar
  25. S. Wang, Z. Chang, and X. Jiang, “A randomized, double-blind, multicenter clinical trial for tangke soft capsules in the treatment of type 2 diabetes,” Chinese Traditional Patent Medicine, vol. 36, no. 10, pp. 2045–2048, 2014. View at Google Scholar
  26. Y. Wangyan-ping, A. Yinha, W. X. Wang et al., “Effect of Liu wei Di huang combined with Ginkgo Leaf on fractalkine in type 2 diabetic patients,” Journal of Southeast University (Medical Science Edition), vol. 33, no. 02, pp. 121–125, 2014. View at Google Scholar
  27. J. Xu, F. Lian, L. Zhao et al., “Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula,” The ISME Journal, vol. 9, no. 3, pp. 552–562, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Hu, X. Zhou, P. Liu, B. Wang, D.-M. Duan, and D.-H. Guo, “A comparison study of metformin only therapy and metformin combined with Chinese medicine jianyutangkang therapy in patients with type 2 diabetes: A randomized placebo-controlled double-blind study,” Complementary Therapies in Medicine, vol. 24, pp. 13–18, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Viswanathan, M. T. Ansari, N. D. Berkman et al., “Assessing the risk of bias of individual studies in systematic reviews of health care interventions - methods guide for effectiveness and comparative effectiveness reviews,” Agency for Healthcare Research and Quality, 2012. View at Publisher · View at Google Scholar
  30. C. Mendoza, P. Kraemer, P. Herrera, P. Burdiles, D. Sepulveda, and E. Nunez, “Clinical guidelines using the grade system (grading of recommendations assessment development and evaluation),” Revista medica de Chile, vol. 145, no. 11, pp. 1463–1470, 2017. View at Publisher · View at Google Scholar
  31. S. E. Inzucchi, R. M. Bergenstal, J. B. Buse et al., “Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the study of diabetes (EASD),” Diabetologia, vol. 55, no. 6, pp. 1577–1597, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. A. F. Ceylan-Isik, R. M. Fliethman, L. E. Wold, and J. Ren, “Herbal and traditional Chinese medicine for the treatment of cardiovascular complications in diabetes mellitus,” Current Diabetes Reviews, vol. 4, no. 4, pp. 320–328, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. X. Hu, J. Sato, G. Bajotto et al., “Goshajinkigan (Chinese herbal medicine niu-che-sen-qi-wan) improves insulin resistance in diabetic rats via the nitric oxide pathway.,” Nagoya Journal of Medical Science, vol. 72, no. 1-2, pp. 35–42, 2010. View at Google Scholar · View at Scopus
  34. H. J. Kim, K. H. Chun, D. J. Kim, S. J. Han, Y. S. Kim, and J. T. Woo, “Utilization patterns and cost of complementary and alternative medicine compared to conventional medicine in patients with type 2 diabetes mellitus,” Diabetes Research Clinical Practice, vol. 93, no. 1, pp. 115–122, 2011. View at Publisher · View at Google Scholar
  35. A. Alqahtani, K. Hamid, A. Kam et al., “The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications,” Current Medicinal Chemistry, vol. 20, no. 7, pp. 908–931, 2013. View at Google Scholar · View at Scopus
  36. K. B. Thomas and C. Tesch, Clinical TrIal Disclosure: The Ongoing Debate on Public Registers for Clinical Trials, 2007.
  37. J. J. Gagnier, H. Boon, P. Rochon, D. Moher, J. Barnes, and C. Bombardier, “Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement,” Annals of Internal Medicine, vol. 144, no. 5, pp. 364–367, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. L. L. Kjaergard, J. Villumsen, and C. Gluud, “Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses,” Annals of Internal Medicine, vol. 149, no. 3, pp. 982–989, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Wang, C.-L. Xie, D.-L. Fu et al., “Clinical efficacy and safety of Chinese herbal medicine for Wilson's disease: A systematic review of 9 randomized controlled trials,” Complementary Therapies in Medicine, vol. 20, no. 3, pp. 143–154, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. I. Boutron, D. G. Altman, D. Moher et al., “CONSORT statement for randomized trials of nonpharmacologic treatments: a 2017 update and a CONSORT extension for nonpharmacologic trial abstracts,” Annals of Internal Medicine, vol. 167, no. 1, pp. 40–47, 2017. View at Publisher · View at Google Scholar · View at Scopus