Adenosine Attenuates LPS-Induced Cardiac Dysfunction by Inhibition of Mitochondrial Function via the ER Pathway

Figure 2

Effects of adenosine on proinflammatory cytokine levels in LPS-induced septic rats as assessed by ELISA. Female and male rats received LPS (10 mg/kg, i.p., 2 h) prior to gavage with different doses of adenosine. (a) Effects of different doses of adenosine on TNF-α. (b) Effects of different doses of adenosine on IL-6. (c) Effects of different doses of adenosine on PCT. (d) Effects of different doses of adenosine on cTnI. X ± SD, n = 8 rats per group, P < 0.05, P < 0.01 versus female model group; P < 0.01, P < 0.01 versus male model group; P < 0.05 versus male rats in each group.

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