Adenosine Attenuates LPS-Induced Cardiac Dysfunction by Inhibition of Mitochondrial Function via the ER Pathway

Figure 3

Effects of adenosine on the MAPK signaling pathway in LPS-induced septic rats as assessed by CBA. Female and male rats received LPS (10 mg/kg, i.p., 2 h) prior to gavage with different doses of adenosine. (a) Effects of different doses of adenosine on the phosphorylation of ERK. (b) Effects of different doses of adenosine on the phosphorylation of JNK. (c) Effects of different doses of adenosine on the phosphorylation of p38. X ± SD, n = 8 rats per group, P < 0.05, P < 0.01 versus female model group; P < 0.01, P < 0.01 versus male model group; P < 0.05 versus male rats in each group.

(a)

(b)

(c)