Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 1 / Review Article
Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice Table 1 Possible herb-herb interactions.
Herb 1 Herb 2 Monitoring indexes Pharmacokinetic parameters of indexes comparing to administration herb 1 alone Ref. t1/2 K CL Borneolum Guanxin Shutong Capsule Camphor ↓ ↓ ↓ Isoborneol ↓ ↓ ↑ ↓ Borneol ↓ ↓ ↓ Eugenol ↑ ↑ ↑ ↑ ↓ Syzigium aromaticum Camphor ↓ ↓ [45 ] Isoborneol ↓ Borneol ↓ Eugenol ↑ ↓ Salviae miltiorrhizae Borneol Rosmarinic acid ↑ ↑ ↑ Salvianolic acid A ↑ ↑ [46 ] Salvianolic acid B ↑ ↑ ↑ Radix et Rhizoma Rhei Dahuang-Fuzi Decoction Chrysophanol ↓ ↓ ↑ ↑ ↓ [43 ] Physcion ↓ ↓ ↑ ↓ Paeonia lactiflora Zengmian Yiliu Formula Albiflorin ↓ ↓ ↓ ↑ ↑ [47 ] Paeoniflorin - Radix Kansui and Radix et Rhizoma Glycyrrhizae Gansui-Banxia Decoction Liquiritigenin ↑ ↑ ↑ ↓ ↑ Isoliquiritigenin ↑ ↑ ↑ ↑ ↑ Liquiritin ↓ ↓ ↑ ↓ ↑ [48 ] Glycyrrhetinic acid ↑ ↑ ↓ ↑ Glycyrrhizic acid ↑ ↑ ↑ Radix Paeoniae Radix et Rhizoma Glycyrrhizae Liquiritigenin ↑ ↑ ↑ Isoliquiritigenin ↑ ↑ ↑ Liquiritin ↑ ↑ ↑ ↑ ↑ [48 ] Glycyrrhetinic acid ↑ ↑ ↑ ↑ Glycyrrhizic acid ↑ ↑ ↑ ↑ Cortex Mori Radix Pueraria Flavonoids1-deoxynojirimycin ↑ ↑ ↑ [49 ] Ramulus Cinnamomi Ephedrae Herba Coumarin ↑ ↑ ↑ ↑ ↑ Cinnamic alcohol ↑ ↑ ↑ [50 ] Cinnamic acid ↑ ↑ ↓ ↑ ↑ Huo Luo Xiao Ling Dan Radix Paeoniae Rubra Paeoniflorin ↓ ↓ ↓ ↑ Albiflorin ↓ ↓ ↓ ↑ Oxypaeoniflorin ↓ ↓ ↓ ↑ Corydalis yanhusuo Tetrahydropalmatine ↑ ↑ ↓ ↓ ↑ ↓ [51 ] Corydaline ↑ ↑ ↓ ↑ Dehydrocorydaline ↑ ↑ ↓ ↑ ↓ Berberine ↑ ↑ ↓ ↑ Huo Luo Xiao Ling Dan Radix Angelica sinensis and Rhizome Ligusticum chuanxiong Senkyunolide A ↑ ↑ Ligustilide ↑ ↑ ↓ ↑ Butylidenephthalide ↑ ↑ ↓ ↓ ↑ [42 ] 3-butyl-phthalide ↑ ↑ ↑ Levistilide A ↑ ↑ ↓ ↓ ↑ Panax Ginseng glycosidesSchisandra lignans Ginsenoside Rb2 ↑ ↑ Ginsenoside Rc ↑ ↑ Ginsenoside Rd ↑ ↑ Ginsenoside Rb1 ↑ ↑ [44 ] Ginsenoside Rb2 ↑ ↑ Ginsenoside Rd ↑ Quercetin and Rutin Leaves of Bacopa monnieri , Fruits of Hippophae rhamnoides and Bulbs of Dioscorea bulbifera Quercetin ↓ ↓ [52 ] Rutin ↑ ↑ ↑ ↑ Radix Paeoniae Alba and Radix et Rhizoma Glycyrrhizae (1:1)Radix Paeoniae Alba and Radix et Rhizoma Glycyrrhizae (4:1)Albiflorin ↑ ↑ ↓ Oxypaeoniflorin ↑ ↑ ↓ Paeoniflorin ↑ ↑ ↓ Isoliquiritin ↑ Liquiritigenin ↑ ↓ [53 ] Isoliquiritigenin ↓ ↓ ↑ Ononin ↑ ↓ Glycyrrhizin ↑ ↑ ↓ Glycyrrhetinic acid ↓ ↓ Rhizoma Tianma Ferulic acid Gastrodin ↑ ↑ ↓ [54 ] Total phenolic acid of Rhizoma Chuanxiong Gastrodin ↑ ↑ Rhizoma Tianma Total alkaloids of Rhizoma Chuanxiong Gastrodin ↑ [54 ] Rhizoma Chuanxiong Gastrodin ↑ ↑ ↓ ↑ ↓
Blanks indicate not mentioned or not significant changes.
