Evidence-Based Complementary and Alternative Medicine

Review Article

Influence Factors of the Pharmacokinetics of Herbal Resourced Compounds in Clinical Practice

Table 2

Possible multicomponent interaction in an herb.
HRC1HRC2/HerbMonitoring indexesPharmacokinetic parameters of indexes compared to administration HRC1 aloneRef.
t1/2CL
OstholeLibanotis buchtormensisOsthole↓ ↑↓↓   ↑[55]
Epimedin CHerba EpimediiEpimedin C↓  ↓↓  ↑↑[56]
TectoridinIris tectorumTectoridin↑↑↑ ↑   ↑[57]
EmodinStilbene glucoside of Radix Polygoni MultifloriEmodin↑↑↑ ↑ ↑↑↓[12]
Emodin glucuronide↓↓↑ ↓ ↑↑  
MagnoflorineCortex PhellodendriMagnoflorine↑↑↑↑ ↑↑ ↓[11]
BerberineMagnoflorine↑↑  ↑   ↓ 
Flavonoid fraction of Abelmoschus manihotMacromolecular fraction of Abelmoschus manihotRutin   ↑      
Isoquercitrin  ↓↑↑     
Hibifolin   ↑      
Quercetin-3'-O-glucose   ↑      
Quercetin  ↓↑      
Small molecule fraction of Abelmoschus manihotRutin↑ ↑ ↑    [58]
Hyperiode↑         
Isoquercitrin↑         
Hibifolin↑  ↑      
Myricetin↑  ↑↑     
Quercetin-3'-O-glucose↑   ↑     
Quercetin  ↓       
 Macromolecular and Small molecule fraction of Abelmoschus manihotRutin↑         
Hyperiode↑ ↑↑      
Isoquercitrin↑  ↑      
Hibifolin   ↑     [58]
Myricetin   ↑      
Quercetin-3'-O-glucose↑  ↑      
Quercetin↑ ↓       
Ginkgo flavonoidsGinkgo bilobaApigenin↑  ↓↑ ↓↓↓ 
Luteolin↑  ↑↑ ↑↓↓ 
Naringenin↑  ↑  ↓ ↓ 
Quercetin  ↑↑↑ ↑↑↓[59]
Diosmetin↑  ↑↑  ↓↓ 
Kaempferol↑   ↑ ↑ ↓ 
Isorhamnetin↑   ↑  ↓↓ 
SinomenineSinomenium acutumSinomenine↓↓  ↓  ↑↑[60]