A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats

Table 6

Urinalysis parameters of female rats treated with SHT for 4 weeks.

Dose (mg/kg/day)	0	1000	2000	5000
Male
Volume (mL)	21.4 ± 5.81	14.8 ± 2.28	28.4 ± 8.65	20.2 ± 13.90
Specific gravity	1.010 ± 0.0035	1.013 ± 0.0027	1.011 ± 0.0042	1.011 ± 0.0022
pH	7.0 ± 0.00	6.7 ± 0.27	7.0 ± 0.00	6.7 ± 0.27
Potassium (mmol/L)	108.29 ± 26.694	149.69 ± 27.031	93.26 ± 29.780	95.96 ± 28.503
Chloride (mmol/L)	41.2 ± 9.42	42.0 ± 5.34	34.2 ± 11.30	31.6 ± 8.35
Sodium (mmol/L)	33.6 ± 16.01	38.2 ± 7.09	21.4 ± 14.33	10.6^+ ± 4.62
	0/5	0/5	1/5	4/5
	0/5	0/5	0/5	0/5
Female
Volume (mL)	16.4 ± 3.85	18.6 ± 5.08	16.4 ± 7.92	10.4 ± 4.34
Specific gravity	1.015 ± 0.000	1.013 ± 0.0027	1.015 ± 0.0079	1.017 ± 0.0045
pH	6.6 ± 0.22	6.7 ± 0.45	6.3 ± 0.84	6.2 ± 0.27
Potassium (mmol/L)	123.89 ± 31.436	101.60 ± 34.955	106.01 ± 76.483	112.67 ± 36.457
Chloride (mmol/L)	59.0 ± 8.43	51.8 ± 21.42	57.6 ± 43.18	67.6 ± 21.61
Sodium (mmol/L)	50.2 ± 26.08	40.0 ± 16.69	37.4 ± 23.35	37.2 ± 13.81
	0/5	0/5	1/5	5/5
	0/5	0/5	1/5	3/5

Results are presented as mean ± SD. Number of animals with sign animals/total animal number. ⁺means Dunnett's LSD test significant at the 0.05 level.